Right atrium size in the general population.
Adult
Aged
Atrial Fibrillation
/ diagnostic imaging
Body Mass Index
Coronary Artery Disease
/ diagnostic imaging
Echocardiography
/ methods
Female
Germany
/ epidemiology
Heart Atria
/ anatomy & histology
Heart Failure
/ diagnostic imaging
Humans
Male
Middle Aged
Multivariate Analysis
Reference Values
Risk Factors
Treatment Outcome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 11 2021
18 11 2021
Historique:
received:
07
08
2021
accepted:
28
10
2021
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
26
2
2022
Statut:
epublish
Résumé
Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th-95th: 12.7-30.4 ml/m) and 26.1 ml/m in men (5th-95th: 16.0-40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29-2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits.
Identifiants
pubmed: 34795353
doi: 10.1038/s41598-021-01968-y
pii: 10.1038/s41598-021-01968-y
pmc: PMC8602329
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22523Subventions
Organisme : Federal Ministry of Education and Research
ID : BMBF 01EO1503
Organisme : DIASyM research core
ID : BMBF 161L0217A
Informations de copyright
© 2021. The Author(s).
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