Enrichment of
ALS
NADase
SARM1
genetics
genomics
human
neuroscience
risk allele
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 11 2021
19 11 2021
Historique:
received:
02
06
2021
accepted:
18
11
2021
pubmed:
20
11
2021
medline:
22
1
2022
entrez:
19
11
2021
Statut:
epublish
Résumé
SARM1, a protein with critical NADase activity, is a central executioner in a conserved programme of axon degeneration. We report seven rare missense or in-frame microdeletion human
Identifiants
pubmed: 34796871
doi: 10.7554/eLife.70905
pii: 70905
pmc: PMC8735862
doi:
pii:
Substances chimiques
Armadillo Domain Proteins
0
Cytoskeletal Proteins
0
SARM1 protein, human
0
Nicotinamide Mononucleotide
1094-61-7
NAD+ Nucleosidase
EC 3.2.2.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/L501529/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220906/Z/20/Z
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : U54 NS065712
Pays : United States
Organisme : National Institutes of Neurological Diseases and Stroke and office of Rare Diseases
ID : U54NS065712
Organisme : Medical Research Council
ID : MR/R024804/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS072248
Pays : United States
Organisme : NIEHS NIH HHS
ID : K23 ES027221
Pays : United States
Organisme : Wellcome Trust
ID : 216596/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS105755
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S009582/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N004582/1
Pays : United Kingdom
Informations de copyright
© 2021, Gilley et al.
Déclaration de conflit d'intérêts
JG Part-funded by AstraZeneca during the past 3 years, OJ Currently part-funded by AstraZeneca, MP, ME, AA, MD, Kv, SG, MH, HH, AI, JK, LL, JR, GR, RS, JX, SZ, JC, ZG, MR No competing interests declared, MC Consults for Nura Bio, but no support provided for this work
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