Glucose tolerance in fibromyalgia.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
10
07
2021
accepted:
27
10
2021
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
1
2
2022
Statut:
ppublish
Résumé
Fibromyalgia (FM) patients have an increased risk for glucose metabolism disturbances, and impaired glucose tolerance may be associated with symptom severity. Elevated levels of plasma lactate have been detected in FM patients. Both pyruvate and lactate are produced in glucose metabolism and reflect oxidative metabolism. The objective of our study was to analyse disturbances in glucose, pyruvate, or lactate metabolism in FM patients. We measured plasma levels of glucose, pyruvate, and lactate during an oral glucose tolerance test in 40 non-diabetic, female FM patients and 30 age- and gender-matched healthy controls. FM patients showed a higher glycaemic response to the glucose load at 1 hour (F [1,68] = 10.4, P = .006) and 2 hours (F [1,68] = 7.80, P = .02), and higher glucose area under the curve (13.8 [SD 2.92] vs 11.6 [SD 2.31], P < .01), than healthy controls. Group differences were explained by higher body mass index and percentage of smokers among the FM patients. Pyruvate and lactate levels were similar in both groups. Impaired glucose regulation in FM patients is likely not due to FM itself, but to associated lifestyle factors. Our results highlight the importance of assessing the glucose regulation status and the lifestyle factors affecting glucose regulation in FM patients for prevention or early treatment of diabetes and associated complications. ClinicalTrials.gov (NCT03300635).
Identifiants
pubmed: 34797307
doi: 10.1097/MD.0000000000027803
pii: 00005792-202111190-00037
pmc: PMC8601335
doi:
Substances chimiques
Blood Glucose
0
Lactates
0
Pyruvates
0
Glucose
IY9XDZ35W2
Banques de données
ClinicalTrials.gov
['NCT03300635']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e27803Subventions
Organisme : finnish state research funding
ID : TYH2017215
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The other authors have no conflicts of interest to disclose.
Références
Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 1990;33:160–72.
Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 2016;46:319–29.
Markkula RA, Kalso EA, Kaprio JA. Predictors of fibromyalgia: a population-based twin cohort study. BMC Musculoskelet Disord 2016;17:01–11.
Tishler M, Smorodin T, Vazina-Amit M, Ramot Y, Koffler M, Fishel B. Fibromyalgia in diabetes mellitus. Rheumatol Int 2003;23:171–3.
Loevinger BL, Muller D, Alonso C, Coe CL. Metabolic syndrome in women with chronic pain. Metabolism 2007;56:87–93.
Mäntyselkä P, Miettola J, Niskanen L, Kumpusalo E. Glucose regulation and chronic pain at multiple sites. Rheumatology 2008;47:1235–8.
Lichtenstein A, Tiosano S, Comaneshter D, Amital H, Cohen AD, Amital D. Cross-sectional analysis of the associations between fibromyalgia and diabetes mellitus. Reumatologia 2018;56:275–8.
Fava A, Plastino M, Cristiano D, et al. Insulin resistance possible risk factor for cognitive impairment in fibromialgic [sic] patients. Metab Brain Dis 2013;28:619–27.
Mergenthaler P, Lindauer U, Dienel GA, Meisel A. Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci 2013;36:587–97.
Van Hall G, Strømstad M, Rasmussen P, et al. Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 2009;29:1121–9.
Adeva-Andany M, López-Ojén M, Funcasta-Calderón R, et al. Comprehensive review on lactate metabolism in human health. Mitochondrion 2014;17:76–100.
McIver KL, Evans C, Kraus RM, Ispas L, Sciotti VM, Hickner RC. NO-mediated alterations in skeletal muscle nutritive blood flow and lactate metabolism in fibromyalgia. Pain 2006;120:161–9.
Gerdle B, Ernberg M, Mannerkorpi K, et al. Increased interstitial concentrations of glutamate and pyruvate in vastus lateralis of women with Fibromyalgia syndrome are normalized after an exercise intervention - A case-control study. PLoS One 2016;11:01–24.
Gerdle B, Ghafouri B, Ernberg M, Larsson B. Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique. J Pain Res 2014;7:313–26.
Gerdle B, Kristiansen J, Larsson B, Saltin B, Søgaard K, Sjøgaard G. Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study. BMC Musculoskelet Disord 2014;15:01–15.
Proia P, Amato A, Contrò V, et al. Relevance of lactate level detection in migrane [sic] and fibromyalgia. Eur J Transl Myol 2019;29:01–5.
Gerdle B, Larsson B, Forsberg F, et al. Chronic widespread pain: increased glutamate and lactate concentrations in the trapezius muscle and plasma. Clin J Pain 2014;30:409–20.
Adler GK, Kinsley BT, Hurwitz S, Mossey CJ, Goldenberg DL. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med 1999;106:534–43.
McCall-Hosenfeld JS, Goldenberg DL, Hurwitz S, Adler GK. Growth hormone and insulin-like growth factor-1 concentrations in women with fibromyalgia. J Rheumatol 2003;30:809–14.
Kirnap M, Çolak R, Eser C, Özsoy O, Tutus A, Kelestimur F. A comparison between low-dose (1 (g), standard-dose (250 (g) ACTH stimulation tests and insulin tolerance test in the evaluation of hypothalamo-pituitary-adrenal axis in primary fibromyalgia syndrome. Clin Endocrinol (Oxf) 2001;55:455–9.
Zetterman T, Markkula R, Partanen JV, Miettinen T, Estlander A-M, Kalso E. Muscle activity and acute stress in fibromyalgia. BMC Musculoskelet Disord 2021;22:01–13.
Burckhardt CS, Clark SR, B R. The fibromyalgia impact questionnaire: development and validation. J Rheumatol 1991;18:728–33.
Gauffin J, Hankama T, Kautiainen H, Arkela-Kautiainen M, Hannonen P, Haanpää M. Validation of a Finnish version of the Fibromyalgia Impact Questionnaire (Finn-FIQ). Scand J Pain 2012;3:15–20.
Regnell SE, Lernmark Å. Early prediction of autoimmune (type 1) diabetes. Diabetologia 2017;60:1370–81.
Joshipura KJ, Andriankaja MO, Hu FB, Ritchie CS. Relative utility of 1-hr oral glucose tolerance test as a measure of abnormal glucose homeostasis. Diabetes Res Clin Pract 2011;93:268–75.
Tonstad S. Cigarette smoking, smoking cessation, and diabetes. Diabetes Res Clin Pract 2009;85:04–13.
Yuan S, Larsson SC. An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study. Diabetologia 2020;63:2359–71.
Aune D, Norat T, Leitzmann M, Tonstad S, Vatten LJ. Physical activity and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis. Eur J Epidemiol 2015;30:529–42.
Leproult R, Van Cauter E. Role of sleep and sleep loss in hormonal release and metabolism. Endocr Dev 2010;17:11–21.
Tasali E, Leproult R, Spiegel K. Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes. Prog Cardiovasc Dis 2009;51:381–91.
Ursini F, Naty S, Grembiale RD. Fibromyalgia and obesity: the hidden link. Rheumatol Int 2011;31:1403–8.
D’Onghia M, Ciaffi J, Lisi L, et al. Fibromyalgia and obesity: a comprehensive systematic review and meta-analysis. Semin Arthritis Rheum 2021;51:409–24.
Font Gayà T, Bordoy Ferrer C, Juan Mas A, et al. Prevalence of fibromyalgia and associated factors in Spain. Clin Exp Rheumatol 2020;123:47–52.
Mork PJ, Vasseljen O, Nilsen TIL. Association between physical exercise, body mass index, and risk of fibromyalgia: Longitudinal data from the Norwegian Nord-Trøndelag health study. Arthritis Care Res 2010;62:611–7.
Schrepf A, Harte SE, Miller N, et al. Improvement in the spatial distribution of pain, somatic symptoms, and depression following a weight-loss intervention. J Pain 2017;18:1542–50.
Hooper MM, Stellato TA, Hallowell PT, Seitz BA, Moskowitz RW. Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery. Int J Obes 2007;31:114–20.
Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Nutritional interventions in the management of fibromyalgia syndrome. Nutrients 2020;12:01–19.
Pamuk ÖN, Dönmez S, Çakir N. The frequency of smoking in fibromyalgia patients and its association with symptoms. Rheumatol Int 2009;29:1311–4.
Goesling J, Brummett CM, Meraj TS, Moser SE, Hassett AL, Ditre JW. Associations between pain, current tobacco smoking, depression, and fibromyalgia status among treatment-seeking chronic pain patients. Pain Med 2015;16:1433–42.
Yunus MB, Arslan S, Aldag JC. Relationship between fibromyalgia features and smoking. Scand J Rheumatol 2002;31:301–5.
Ge L, D'Souza RS, Oh T, et al. Tobacco use in fibromyalgia is associated with cognitive dysfunction. Mayo Clin Proc Innov Qual Outcomes 2019;3:78–85.
Lee SS, Kim SH, Nah SS, et al. Smoking habits influence pain and functional and psychiatric features in fibromyalgia. Joint Bone Spine 2011;78:259–65.
Bokarewa MI, Erlandsson MC, Bjersing J, Dehlin M, Mannerkorpi K. Smoking is associated with reduced leptin and neuropeptide Y levels and higher pain experience in patients with fibromyalgia. Mediators Inflamm 2014;2014:
Lee C, Liptan G, Kantorovich S, Sharma M, Brenton A. Association of catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients. BMC Rheumatol 2018;2:38doi: 10.1186/s41927-018-0045-4.
doi: 10.1186/s41927-018-0045-4
Weingarten TN, Vincent A, Luedtke CA, et al. The perception of female smokers with fibromyalgia on the effects of smoking on fibromyalgia symptoms. Pain Pract 2016;16:1054–63.
Saragiotto BT, Kamper SJ, Hodder R, et al. Interventions targeting smoking cessation for patients with chronic pain: an evidence synthesis. Nicotine Tob Res 2020;22:135–40.
Huang Y, Cai X, Mai W, Li M, Hu Y. Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis. BMJ 2016;355:i5953.