UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease.
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
20
09
2021
accepted:
24
09
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
A new Mendelian randomization study finds evidence that genetically predicted higher levels of urinary uromodulin are associated with lower kidney function and higher blood pressure. Bidirectional and multivariable Mendelian randomization suggests the association with higher blood pressure appears to be partially through decreased kidney function, but blood pressure does not appear to mediate the association of uromodulin with low kidney function. We describe the methods used for the bidirectional and multivariable Mendelian randomization analyses and examine the validity of the assumptions and implications of the results.
Identifiants
pubmed: 34802557
pii: S0085-2538(21)00930-3
doi: 10.1016/j.kint.2021.09.019
pii:
doi:
Substances chimiques
UMOD protein, human
0
Uromodulin
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1168-1170Subventions
Organisme : Medical Research Council
ID : MC_UU_00017/2
Pays : United Kingdom
Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.