Phosphorylation of Lamin A/C at serine 22 modulates Na


Journal

Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800

Informations de publication

Date de publication:
11 2021
Historique:
revised: 29 10 2021
received: 02 07 2021
accepted: 31 10 2021
entrez: 22 11 2021
pubmed: 23 11 2021
medline: 17 3 2022
Statut: ppublish

Résumé

Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants p.R545H and p.A287Lfs*193, which were identified in CCD patients, decreased peak I

Identifiants

pubmed: 34806324
doi: 10.14814/phy2.15121
pmc: PMC8606869
doi:

Substances chimiques

LMNA protein, human 0
Lamin Type A 0
NAV1.5 Voltage-Gated Sodium Channel 0
SCN5A protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e15121

Subventions

Organisme : NCI NIH HHS
ID : R01 CA211866
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093056
Pays : United States

Informations de copyright

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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Auteurs

Michael A Olaopa (MA)

Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Tomohiko Ai (T)

Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Clinical Laboratory Medicine, Juntendo University, Tokyo, Japan.

Bo Chao (B)

Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.

Xiangshu Xiao (X)

Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.

Matteo Vatta (M)

Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Beth A Habecker (BA)

Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.

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Classifications MeSH