Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
01
03
2021
accepted:
04
11
2021
revised:
06
12
2021
pubmed:
23
11
2021
medline:
31
12
2021
entrez:
22
11
2021
Statut:
epublish
Résumé
Pronounced activity is observed in both hemispheres of the motor cortex during preparation and execution of unimanual movements. The organizational principles of bi-hemispheric signals and the functions they serve throughout motor planning remain unclear. Using an instructed-delay reaching task in monkeys, we identified two components in population responses spanning PMd and M1. A "dedicated" component, which segregated activity at the level of individual units, emerged in PMd during preparation. It was most prominent following movement when M1 became strongly engaged, and principally involved the contralateral hemisphere. In contrast to recent reports, these dedicated signals solely accounted for divergence of arm-specific neural subspaces. The other "distributed" component mixed signals for each arm within units, and the subspace containing it did not discriminate between arms at any stage. The statistics of the population response suggest two functional aspects of the cortical network: one that spans both hemispheres for supporting preparatory and ongoing processes, and another that is predominantly housed in the contralateral hemisphere and specifies unilateral output.
Identifiants
pubmed: 34807905
doi: 10.1371/journal.pcbi.1009615
pii: PCOMPBIOL-D-21-00379
pmc: PMC8648118
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1009615Subventions
Organisme : NIMH NIH HHS
ID : R01 MH117763
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097480
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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