Dissolution/Permeation of Albendazole in the Presence of Cyclodextrin and Bile Salts: A Mechanistic In Vitro Study into Factors Governing Oral Bioavailability.
Bioavailability
Cyclodextrin(s)
Micelle(s)
Permeability
Poorly water-soluble drug(s)
Solubility
Supersaturation
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
30
09
2021
revised:
15
11
2021
accepted:
15
11
2021
pubmed:
23
11
2021
medline:
25
5
2022
entrez:
22
11
2021
Statut:
ppublish
Résumé
We aimed to understand the impact of the interplay between bile salts and cyclodextrins on the dissolution-permeation of poorly soluble drug compounds with a moderate-strong binding constant to cyclodextrin. Phase diagrams were prepared on the chosen model compound albendazole in phosphate buffer, fasted state simulated intestinal fluid (FaSSIF), and a modified fed state simulated intestinal fluid (FeSSIF
Identifiants
pubmed: 34808218
pii: S0022-3549(21)00617-1
doi: 10.1016/j.xphs.2021.11.010
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Cyclodextrins
0
2-Hydroxypropyl-beta-cyclodextrin
1I96OHX6EK
Albendazole
F4216019LN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1667-1673Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.