RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells.

Animals B-Lymphocytes / metabolism Cell Cycle / genetics Core Binding Factor Alpha 2 Subunit / genetics Hematopoiesis Mice Promoter Regions, Genetic

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 12 2021
Historique:
received: 04 12 2020
accepted: 28 09 2021
pubmed: 24 11 2021
medline: 14 7 2022
entrez: 23 11 2021
Statut: ppublish

Résumé

RUNX1 is a transcription factor that plays key roles in hematopoietic development and in hematopoiesis and lymphopoiesis. In this article, we report that RUNX1 regulates a gene expression program in naive mouse B cells that affects the dynamics of cell cycle entry in response to stimulation of the BCR. Conditional knockout of

Identifiants

DOI: 10.4049/jimmunol.2001367 PMID: 34810221 PMC: PMC8675107
pubmed: 34810221
pii: jimmunol.2001367
doi: 10.4049/jimmunol.2001367
pmc: PMC8675107
doi:

Substances chimiques

Core Binding Factor Alpha 2 Subunit 0
Runx1 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2976-2991

Subventions

Organisme : Medical Research Council
ID : MC_U120036884
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1605/8
Pays : United Kingdom

Informations de copyright

Copyright © 2021 by The Authors.

Auteurs

Inesa Thomsen (I)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom.

Natalia Kunowska (N)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom.

Roshni de Souza (R)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom.
ORCID: 0000-0002-8288-588X

Anne-Marie Moody (AM)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom.

Greg Crawford (G)

Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.

Yi-Fang Wang (YF)

Bioinformatics and Computing, MRC London Institute of Medical Sciences, London, United Kingdom.

Sanjay Khadayate (S)

Bioinformatics and Computing, MRC London Institute of Medical Sciences, London, United Kingdom.

Chad Whilding (C)

Microscopy Facility, MRC London Institute of Medical Sciences, London, United Kingdom.

Jessica Strid (J)

Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
ORCID: 0000-0003-3690-2201

Mohammad M Karimi (MM)

Bioinformatics and Computing, MRC London Institute of Medical Sciences, London, United Kingdom.
Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom.
ORCID: 0000-0001-5017-1252

Alexis R Barr (AR)

Cell Cycle Control Group, MRC London Institute of Medical Sciences, London, United Kingdom; and.
Institute of Clinical Sciences, Imperial College London, London, United Kingdom.
ORCID: 0000-0002-6684-8114

Niall Dillon (N)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom; niall.dillon@lms.mrc.ac.uk pierangela.sabbattini@imperial.ac.uk.
Institute of Clinical Sciences, Imperial College London, London, United Kingdom.

Pierangela Sabbattini (P)

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, London, United Kingdom; niall.dillon@lms.mrc.ac.uk pierangela.sabbattini@imperial.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBF › Sous-unités alpha du facteur CBF › Sous-unité alpha 2 du facteur CBF › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › RUNX1 Regulates a Transcription Program That...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › RUNX1 Regulates a Transcription Program That...