Safety evaluation of high-risk myocardial micro-biopsy in a swine model.
Endomyocardial biopsy
Interventional cardiology
Micro-biopsy
Safety
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
28
07
2021
accepted:
12
11
2021
pubmed:
24
11
2021
medline:
7
4
2022
entrez:
23
11
2021
Statut:
ppublish
Résumé
The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.
Identifiants
pubmed: 34812914
doi: 10.1007/s00380-021-01995-9
pii: 10.1007/s00380-021-01995-9
pmc: PMC8917023
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-704Informations de copyright
© 2021. The Author(s).
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