BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
30 11 2021
Historique:
accepted: 15 10 2021
entrez: 24 11 2021
pubmed: 25 11 2021
medline: 28 12 2021
Statut: ppublish

Résumé

Carriers of heterozygous germline

Identifiants

pubmed: 34815344
pii: 2111946118
doi: 10.1073/pnas.2111946118
pmc: PMC8640737
pii:
doi:

Substances chimiques

BAP1 protein, mouse 0
Biomarkers, Tumor 0
HMGB1 Protein 0
HMGB1 protein, mouse 0
Tumor Suppressor Proteins 0
Ubiquitin 0
Asbestos 1332-21-4
Ubiquitin Thiolesterase EC 3.4.19.12
Hdac1 protein, mouse EC 3.5.1.98
Histone Deacetylase 1 EC 3.5.1.98

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01 CA198138
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237235
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030948
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214195
Pays : United States

Déclaration de conflit d'intérêts

Competing interest statement: M.C. has a patent issued for BAP1. M.C. and H.Y. have two patents issued for HMGB1. M.C. is a board-certified pathologist who provides consultation for pleural pathology, including medical–legal.

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Auteurs

Flavia Novelli (F)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Angela Bononi (A)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Qian Wang (Q)

Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.
Hefei National Laboratory for Physical Sciences at the Microscale, Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.

Fang Bai (F)

Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.

Simone Patergnani (S)

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.

Franz Kricek (F)

NBS-C BioScience & Consulting GmbH, Vienna 1230, Austria.

Ellinor Haglund (E)

Department of Chemistry, University of Hawaii, Honolulu, HI 96822.

Joelle S Suarez (JS)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Mika Tanji (M)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Ronghui Xu (R)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Yasutaka Takanishi (Y)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Michael Minaai (M)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Sandra Pastorino (S)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Paul Morris (P)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Greg Sakamoto (G)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Harvey I Pass (HI)

Department of Cardiothoracic Surgery, New York University, New York, NY 10016.

Haithem Barbour (H)

Department of Medicine, University of Montreal, Montreal, QC H1T 2M4, Canada.

Giovanni Gaudino (G)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.

Carlotta Giorgi (C)

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.

Paolo Pinton (P)

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.

Jose N Onuchic (JN)

Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.

Haining Yang (H)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816; mcarbone@cc.hawaii.edu haining@hawaii.edu.

Michele Carbone (M)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816; mcarbone@cc.hawaii.edu haining@hawaii.edu.

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Classifications MeSH