Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
entrez:
24
11
2021
pubmed:
25
11
2021
medline:
17
3
2022
Statut:
ppublish
Résumé
Prenatal exposure to mixtures of nonpersistent chemicals is universal. Most studies examining these chemicals in association with fetal growth have been restricted to single exposure models, ignoring their potentially cumulative impact. We aimed to assess the association between prenatal exposure to a mixture of phthalates, bisphenols, and organophosphate (OP) pesticides and fetal measures of head circumference, femur length, and weight. Within the Generation R Study, a population-based cohort in Netherlands ( The average EFW at 18-25 wk and Higher exposure to a mixture of phthalates, bisphenols, and OP pesticides was associated with lower EFW in the midpregnancy period. In late pregnancy, these differences were similar but less pronounced. At birth, the only associations observed appeared when comparing individuals from Q1 and Q4. This finding suggests that even low levels of exposure may be sufficient to influence growth in early pregnancy, whereas higher levels may be necessary to affect birth weight. Joint exposure to nonpersistent chemicals may adversely impact fetal growth, and because these exposures are widespread, this impact could be substantial. https://doi.org/10.1289/EHP9178.
Sections du résumé
BACKGROUND
Prenatal exposure to mixtures of nonpersistent chemicals is universal. Most studies examining these chemicals in association with fetal growth have been restricted to single exposure models, ignoring their potentially cumulative impact.
OBJECTIVE
We aimed to assess the association between prenatal exposure to a mixture of phthalates, bisphenols, and organophosphate (OP) pesticides and fetal measures of head circumference, femur length, and weight.
METHODS
Within the Generation R Study, a population-based cohort in Netherlands (
RESULTS
The average EFW at 18-25 wk and
DISCUSSION
Higher exposure to a mixture of phthalates, bisphenols, and OP pesticides was associated with lower EFW in the midpregnancy period. In late pregnancy, these differences were similar but less pronounced. At birth, the only associations observed appeared when comparing individuals from Q1 and Q4. This finding suggests that even low levels of exposure may be sufficient to influence growth in early pregnancy, whereas higher levels may be necessary to affect birth weight. Joint exposure to nonpersistent chemicals may adversely impact fetal growth, and because these exposures are widespread, this impact could be substantial. https://doi.org/10.1289/EHP9178.
Identifiants
pubmed: 34817287
doi: 10.1289/EHP9178
pmc: PMC8612241
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117008Subventions
Organisme : Intramural NIH HHS
ID : ZIA ES101575
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022972
Pays : United States
Organisme : NIEHS NIH HHS
ID : HHSN273201500003C
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029779
Pays : United States
Organisme : NIEHS NIH HHS
ID : HHSN273201500003O
Pays : United States
Commentaires et corrections
Type : CommentIn
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