Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry.
Adenine
/ analogs & derivatives
Agammaglobulinaemia Tyrosine Kinase
/ chemistry
Catalytic Domain
Coronavirus Papain-Like Proteases
/ chemistry
Fluorescent Dyes
/ chemistry
Half-Life
Humans
Ligands
Piperidines
/ chemistry
Proteolysis
Proto-Oncogene Proteins p21(ras)
/ antagonists & inhibitors
Pyrimidines
/ chemistry
SARS-CoV-2
/ enzymology
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
08 12 2021
08 12 2021
Historique:
pubmed:
25
11
2021
medline:
16
12
2021
entrez:
24
11
2021
Statut:
ppublish
Résumé
Chemical modifications of native proteins can affect their stability, activity, interactions, localization, and more. However, there are few nongenetic methods for the installation of chemical modifications at a specific protein site in cells. Here we report a covalent ligand directed release (CoLDR) site-specific labeling strategy, which enables the installation of a variety of functional tags on a target protein while releasing the directing ligand. Using this approach, we were able to label various proteins such as BTK, K-Ras
Identifiants
pubmed: 34817989
doi: 10.1021/jacs.1c06167
pmc: PMC8662641
doi:
Substances chimiques
Fluorescent Dyes
0
KRAS protein, human
0
Ligands
0
Piperidines
0
Pyrimidines
0
ibrutinib
1X70OSD4VX
Agammaglobulinaemia Tyrosine Kinase
EC 2.7.10.2
Coronavirus Papain-Like Proteases
EC 3.4.22.2
papain-like protease, SARS-CoV-2
EC 3.4.22.2
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Adenine
JAC85A2161
evobrutinib
ZA45457L1K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20095-20108Références
Chem Commun (Camb). 2020 Feb 4;56(10):1521-1524
pubmed: 31922153
ACS Med Chem Lett. 2021 Jul 21;12(8):1302-1307
pubmed: 34413960
Future Med Chem. 2015;7(8):975-8
pubmed: 26062395
Nat Methods. 2005 Mar;2(3):207-12
pubmed: 15782190
Bioconjug Chem. 2018 May 16;29(5):1640-1645
pubmed: 29652138
J Am Chem Soc. 2018 Mar 21;140(11):4004-4017
pubmed: 29473744
Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292
pubmed: 30012605
Nat Biotechnol. 2001 Nov;19(11):1042-6
pubmed: 11689849
Angew Chem Int Ed Engl. 2009;48(38):6974-98
pubmed: 19714693
Nat Chem Biol. 2015 Dec;11(12):917-23
pubmed: 26575238
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):21880-21884
pubmed: 32762146
Mol Biol Cell. 2017 Apr 1;28(7):848-857
pubmed: 28360214
Trends Biotechnol. 2010 Feb;28(2):73-83
pubmed: 19962774
Nat Chem. 2020 Feb;12(2):165-172
pubmed: 31792385
RSC Chem Biol. 2020 May 19;1(2):56-59
pubmed: 34458748
Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4372-4385
pubmed: 28994500
FEBS J. 2007 Feb;274(3):815-26
pubmed: 17288561
Chem Commun (Camb). 2014 Dec 18;50(97):15319-22
pubmed: 25347137
Curr Opin Chem Biol. 2021 Jun;62:24-33
pubmed: 33549806
Chem Commun (Camb). 2019 Jan 17;55(7):929-932
pubmed: 30601480
ACS Chem Biol. 2008 Jun 20;3(6):373-82
pubmed: 18533659
ChemMedChem. 2007 Jan;2(1):58-61
pubmed: 17154430
Nat Chem. 2016 Feb;8(2):120-8
pubmed: 26791894
J Pathol. 2010 Jun;221(2):117-24
pubmed: 20225337
Curr Opin Chem Biol. 2019 Jun;50:111-119
pubmed: 31004963
Nat Chem Biol. 2009 May;5(5):341-3
pubmed: 19330012
ACS Chem Biol. 2018 Jul 20;13(7):1880-1889
pubmed: 29437380
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21984-9
pubmed: 19995983
J Am Chem Soc. 2018 Nov 7;140(44):15114-15123
pubmed: 30336012
Blood. 2019 Feb 28;133(9):952-961
pubmed: 30545835
Chem Rev. 2014 May 14;114(9):4764-806
pubmed: 24655057
J Am Chem Soc. 2019 Feb 20;141(7):2782-2799
pubmed: 30592612
J Am Chem Soc. 2003 Jul 9;125(27):8130-3
pubmed: 12837082
Curr Opin Chem Biol. 2015 Aug;27:10-7
pubmed: 26043278
Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6
pubmed: 31883964
Chem Commun (Camb). 2021 Feb 21;57(15):1875-1878
pubmed: 33427257
ACS Chem Biol. 2018 Mar 16;13(3):553-560
pubmed: 29356495
J Am Chem Soc. 2012 Feb 1;134(4):2216-26
pubmed: 22220821
Cell Chem Biol. 2021 Jul 15;28(7):952-968
pubmed: 33789091
J Am Chem Soc. 2012 Mar 7;134(9):3961-4
pubmed: 22352855
J Pharmacol Exp Ther. 2017 Nov;363(2):240-252
pubmed: 28882879
J Am Chem Soc. 2020 Aug 19;142(33):14052-14057
pubmed: 32787262
Cell Chem Biol. 2021 Jun 22;:
pubmed: 34174194
Nature. 2016 Jun 22;535(7611):252-7
pubmed: 27338790
ACS Chem Biol. 2019 Mar 15;14(3):342-347
pubmed: 30807093
Sci Rep. 2016 Sep 08;6:32866
pubmed: 27605302
Chem Biol. 2013 Feb 21;20(2):146-59
pubmed: 23438744
Nat Rev Drug Discov. 2019 Mar 6;:
pubmed: 30936511
Chem Rev. 2002 Mar;102(3):759-81
pubmed: 11890756
Chem Commun (Camb). 2017 Nov 14;53(88):11972-11983
pubmed: 29026906
Chem Sci. 2015 Oct 1;6(10):5419-5425
pubmed: 28717444
Chem Rev. 2015 Mar 11;115(5):2174-95
pubmed: 25700113
J Org Chem. 2014 Nov 21;79(22):10727-33
pubmed: 25333794
Nat Commun. 2020 Aug 26;11(1):4268
pubmed: 32848159
J Biophotonics. 2011 Jun;4(6):391-402
pubmed: 21567974
Mol Cell. 2003 Dec;12(6):1615-24
pubmed: 14690613
Chem Sci. 2015 May 1;6(5):3217-3224
pubmed: 28706692
Cell Res. 2018 Jul;28(7):779-781
pubmed: 29875397
Science. 1998 Jul 10;281(5374):269-72
pubmed: 9657724
Nat Chem. 2015 Jul;7(7):554-561
pubmed: 26100803
Nat Commun. 2019 Jun 10;10(1):2539
pubmed: 31182711
Curr Opin Biotechnol. 2017 Dec;48:61-68
pubmed: 28395178
Cell. 2020 Apr 2;181(1):102-114
pubmed: 31955850
Nat Commun. 2014 Sep 05;5:4740
pubmed: 25190082
Biochemistry. 2018 Jul 3;57(26):3564-3575
pubmed: 29851337
ACS Chem Biol. 2020 Oct 16;15(10):2722-2730
pubmed: 32865967
Angew Chem Int Ed Engl. 2018 Jan 15;57(3):659-662
pubmed: 29193552
J Am Chem Soc. 2020 Jul 8;142(27):11734-11742
pubmed: 32369353
Nat Chem Biol. 2014 Sep;10(9):760-767
pubmed: 25038787
Nat Commun. 2018 May 14;9(1):1870
pubmed: 29760386
Chem Soc Rev. 2017 Aug 14;46(16):4895-4950
pubmed: 28660957
Nat Chem Biol. 2015 May;11(5):326-31
pubmed: 25822913
Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877
pubmed: 31879210
J Am Chem Soc. 2021 Apr 7;143(13):4979-4992
pubmed: 33761747