The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
pubmed:
25
11
2021
medline:
29
3
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
ELMODs are a family of three mammalian paralogues that display GTPase-activating protein (GAP) activity toward a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expressed in mammalian tissues, highly conserved across eukaryotes, and ancient in origin, being present in the last eukaryotic common ancestor. We described functions of ELMOD2 in immortalized mouse embryonic fibroblasts (MEFs) in the regulation of cell division, microtubules, ciliogenesis, and mitochondrial fusion. Here, using similar strategies with the paralogues ELMOD1 and ELMOD3, we identify novel functions and locations of these cell regulators and compare them to those of ELMOD2, allowing the determination of functional redundancy among the family members. We found strong similarities in phenotypes resulting from deletion of either
Identifiants
pubmed: 34818063
doi: 10.1091/mbc.E21-09-0443
pmc: PMC9236152
doi:
Substances chimiques
Cytoskeletal Proteins
0
ELMOD3 protein, human
0
Elmod1 protein, mouse
0
GTPase-Activating Proteins
0
ADP-Ribosylation Factors
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
ar13Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM122568
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD096815
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122549
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110663
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA236493
Pays : United States
Commentaires et corrections
Type : ErratumIn
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