Fam72a enforces error-prone DNA repair during antibody diversification.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
17
12
2020
accepted:
04
10
2021
pubmed:
26
11
2021
medline:
1
3
2022
entrez:
25
11
2021
Statut:
ppublish
Résumé
Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair. Diversification of B cell receptors through somatic hypermutation and class-switch recombination are initiated by cytidine deamination in DNA mediated by activation-induced cytidine deaminase (AID)
Identifiants
pubmed: 34819671
doi: 10.1038/s41586-021-04093-y
pii: 10.1038/s41586-021-04093-y
doi:
Substances chimiques
Ung protein, mouse
EC 3.2.2
Uracil
56HH86ZVCT
Fam72a protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
329-333Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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