Cytokine storm after heart transplantation in COVID-19-related haemophagocytic lymphohistiocytosis (HLH).
Acute heart failure
COVID-19
Haemophagocytic lymphohistiocytosis syndrome
Haemophagocytosis
Heart transplant
MIS-C
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
17
10
2021
received:
13
02
2021
accepted:
10
11
2021
pubmed:
26
11
2021
medline:
28
1
2022
entrez:
25
11
2021
Statut:
ppublish
Résumé
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily causes inflammation in the respiratory system, there is growing evidence of extrapulmonary tissue damage mediated by the host innate immune system in children and adults. A cytokine storm can manifest as a viral-induced haemophagocytic lymphohistiocytosis (HLH). Here, we present a previously healthy 8-year-old boy with newly diagnosed cardiac injury and COVID-19-related HLH syndrome with haemophagocytosis in bone marrow biopsy. After remission of inflammation, the patient underwent a heart transplant due to persistent cardiac failure. The histology of the explanted heart showed only a focal subtle subendocardial inflammation. Three days after transplant, he developed progressive acute respiratory distress syndrome (ARDS) with the rise of inflammatory markers. He unfortunately died after 20 days because of disseminated intravascular coagulation (DIC). For the first time, we described a child with COVID-19-related HLH and severe cardiac failure, which had a poor prognosis despite a heart transplant.
Identifiants
pubmed: 34821079
doi: 10.1002/ehf2.13728
pmc: PMC8788054
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-223Informations de copyright
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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