Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.

DNA / metabolism Humans Interleukin-2 / metabolism Ligands

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
09 12 2021
Historique:
pubmed: 26 11 2021
medline: 22 1 2022
entrez: 25 11 2021
Statut: ppublish

Résumé

Interleukin-2 (IL2) is a pro-inflammatory cytokine that plays a crucial role in immunity, which is increasingly being used for therapeutic applications. There is growing interest in developing IL2-based therapeutics which do not interact with the alpha subunit of the IL2 receptor (CD25) as this protein is primarily found on immunosuppressive regulatory T cells (T

Identifiants

DOI: 10.1021/acs.jmedchem.1c01693 PMID: 34821503
pubmed: 34821503
doi: 10.1021/acs.jmedchem.1c01693
doi:

Substances chimiques

IL2 protein, human 0
Interleukin-2 0
Ligands 0
DNA 9007-49-2

Types de publication

Journal Article Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

17496-17510

Auteurs

Adrián Gironda-Martínez (A)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
ORCID: 0000-0001-9707-9277

Émile M D Gorre (ÉMD)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.

Luca Prati (L)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.

Jean-François Gosalbes (JF)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.

Sheila Dakhel (S)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.

Samuele Cazzamalli (S)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
ORCID: 0000-0003-0510-5664

Florent Samain (F)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
ORCID: 0000-0001-8278-351X

Etienne J Donckele (EJ)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
ORCID: 0000-0001-9112-1753

Dario Neri (D)

Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland.
Philogen S.p.A, 53100 Siena, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Identification and Validation of New...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification and Validation of New...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Identification and Validation of New...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Identification and Validation of New...