Samuele Cazzamalli

Affiliations

Philochem AG, Otelfingen, Zurich, Switzerland. samuele.cazzamalli@philochem.ch.

Publications (34)

Immunotherapy with Immunocytokines and PD-1 Blockade Enhances the Anticancer Activity of Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX.

Molecular cancer therapeutics

Avec: Jacopo Millul , Christiane Krudewig , Aureliano Zana , Sheila Dakhel Plaza , Emanuele Puca , Alessandra Villa , Dario Neri , Samuele Cazzamalli

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jacopo Millul , Gabriele Bassi , Jacqueline Mock , Abdullah Elsayed , Christian Pellegrino , Aureliano Zana , Sheila Dakhel Plaza , Lisa Nadal , Andreas Gloger , Eleonore Schmidt , Ilaria Biancofiore , Etienne J Donckele , Florent Samain , Dario Neri , Samuele Cazzamalli

Frontiers in pharmacology

Avec: Lydia Bisbal Lopez , Domenico Ravazza , Matilde Bocci , Aureliano Zana , Lucrezia Principi , Sheila Dakhel Plaza , Andrea Galbiati , Ettore Gilardoni , Jörg Scheuermann , Dario Neri , Luca Pignataro , Cesare Gennari , Samuele Cazzamalli , Alberto Dal Corso

Cross-reactivity to glutamate carboxypeptidase III causes undesired salivary gland and kidney uptake of PSMA-targeted small-molecule radionuclide therapeutics.

European journal of nuclear medicine and molecular imaging

Avec: Laura Lucaroni , Tony Georgiev , Eleonora Prodi , Sara Puglioli , Christian Pellegrino , Nicholas Favalli , Luca Prati , Markus G Manz , Samuele Cazzamalli , Dario Neri , Sebastian Oehler , Gabriele Bassi

Impact of Ligand Size and Conjugation Chemistry on the Performance of Universal Chimeric Antigen Receptor T-Cells for Tumor Killing.

Bioconjugate chemistry

Avec: Christian Pellegrino , Nicholas Favalli , Michael Sandholzer , Laura Volta , Gabriele Bassi , Jacopo Millul , Samuele Cazzamalli , Mattia Matasci , Alessandra Villa , Renier Myburgh , Markus G Manz , Dario Neri

A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Avec: Andrea Galbiati , Aureliano Zana , Matilde Bocci , Jacopo Millul , Abdullah Elsayed , Jacqueline Mock , Dario Neri , Samuele Cazzamalli

Mass Spectrometry-Based Method for the Determination of the Biodistribution of Tumor-Targeting Small Molecule-Metal Conjugates.

Analytical chemistry

Avec: Ettore Gilardoni , Aureliano Zana , Andrea Galbiati , Theo Sturm , Jacopo Millul , Samuele Cazzamalli , Dario Neri , Riccardo Stucchi

Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Aureliano Zana , Andrea Galbiati , Ettore Gilardoni , Matilde Bocci , Jacopo Millul , Theo Sturm , Riccardo Stucchi , Abdullah Elsayed , Lisa Nadal , Martina Cirillo , Wolfgang Roll , Lars Stegger , Inga Asmus , Philipp Backhaus , Michael Schäfers , Dario Neri , Samuele Cazzamalli

A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition.

Nature chemistry

Avec: Sebastian Oehler , Laura Lucaroni , Francesca Migliorini , Abdullah Elsayed , Luca Prati , Sara Puglioli , Mattia Matasci , Kristina Schira , Jörg Scheuermann , Denis Yudin , Min Jia , Nenad Ban , Dave Bushnell , Roger Kornberg , Samuele Cazzamalli , Dario Neri , Nicholas Favalli , Gabriele Bassi

Impact of library input on the hit discovery rate in DNA-encoded chemical library selections.

Chemical science

Avec: Sara Puglioli , Sebastian Oehler , Luca Prati , Jörg Scheuermann , Gabriele Bassi , Samuele Cazzamalli , Dario Neri , Nicholas Favalli

Cytokine Biopharmaceuticals with "Activity-on-Demand" for Cancer Therapy.

Bioconjugate chemistry

Avec: Giulia Rotta , Emanuele Puca , Samuele Cazzamalli , Dario Neri , Sheila Dakhel Plaza

Antibody-based delivery of interleukin-9 to neovascular structures: Therapeutic evaluation in cancer and arthritis.

Experimental biology and medicine (Maywood, N.J.)

Avec: Baptiste Gouyou , Tiziano Ongaro , Samuele Cazzamalli , Roberto De Luca , Anne Kerschenmeyer , Philippe Valet , Alessandra Villa , Dario Neri , Mattia Matasci

A novel anti-cancer L19-interleukin-12 fusion protein with an optimized peptide linker efficiently localizes in vivo at the site of tumors.

Journal of biotechnology

Avec: Tiziano Ongaro , Mattia Matasci , Samuele Cazzamalli , Baptiste Gouyou , Roberto De Luca , Dario Neri , Alessandra Villa

Translational imaging of the fibroblast activation protein (FAP) using the new ligand [

European journal of nuclear medicine and molecular imaging

Avec: P Backhaus , F Gierse , M C Burg , F Büther , I Asmus , P Dorten , J Cufe , W Roll , D Neri , S Cazzamalli , J Millul , J Mock , A Galbiati , A Zana , K P Schäfers , S Hermann , M Weckesser , J Tio , S Wagner , H-J Breyholz , M Schäfers

In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Matilde Bocci , Aureliano Zana , Lucrezia Principi , Laura Lucaroni , Luca Prati , Ettore Gilardoni , Dario Neri , Samuele Cazzamalli , Andrea Galbiati

Discovery of Glutamate Carboxypeptidase III Ligands to Compete the Uptake of [

Journal of medicinal chemistry

Avec: Marco Müller , Laura Lucaroni , Nicholas Favalli , Gabriele Bassi , Dario Neri , Samuele Cazzamalli , Sebastian Oehler

Automated Radiosynthesis, Preliminary In Vitro/In Vivo Characterization of OncoFAP-Based Radiopharmaceuticals for Cancer Imaging and Therapy.

Pharmaceuticals (Basel, Switzerland)

Avec: Francesco Bartoli , Philip Elsinga , Luiza Reali Nazario , Aureliano Zana , Andrea Galbiati , Jacopo Millul , Francesca Migliorini , Samuele Cazzamalli , Dario Neri , Riemer H J A Slart , Paola Anna Erba

Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Avec: Andrea Galbiati , Paulina Dorten , Ettore Gilardoni , Florian Gierse , Matilde Bocci , Aureliano Zana , Jacqueline Mock , Michael Claesener , Juela Cufe , Florian Büther , Klaus Schäfers , Sven Hermann , Michael Schäfers , Dario Neri , Samuele Cazzamalli , Philipp Backhaus

Automated and enhanced extraction of a small molecule-drug conjugate using an enzyme-inhibitor interaction based SPME tool followed by direct analysis by ESI-MS.

Analytical and bioanalytical chemistry

Avec: Sahar Ghiasikhou , Samuele Cazzamalli , Jörg Scheuermann , Dario Neri , Renato Zenobi

Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.

Journal of medicinal chemistry

Avec: Adrián Gironda-Martínez , Émile M D Gorre , Luca Prati , Jean-François Gosalbes , Sheila Dakhel , Samuele Cazzamalli , Florent Samain , Etienne J Donckele , Dario Neri

Isolation of a Natural Killer Group 2D Small-Molecule Ligand from DNA-Encoded Chemical Libraries.

ChemMedChem

Avec: Sheila Dakhel , Andrea Galbiati , Francesca Migliorini , Claudia Comacchio , Sebastian Oehler , Luca Prati , Jörg Scheuermann , Samuele Cazzamalli , Dario Neri , Gabriele Bassi , Nicholas Favalli

Targeted interleukin-2 enhances the in vivo anti-cancer activity of Pluvicto™.

European journal of nuclear medicine and molecular imaging

Avec: Tony Georgiev , Lucrezia Principi , Andrea Galbiati , Ettore Gilardoni , Dario Neri , Samuele Cazzamalli

Permutational Encoding Strategy Accelerates HIT Validation from Single-Stranded DNA-Encoded Libraries.

Bioconjugate chemistry

Avec: Sara Puglioli , Mosè Fabbri , Claudia Comacchio , Laura Alvigini , Roberto De Luca , Sebastian Oehler , Ettore Gilardoni , Gabriele Bassi , Samuele Cazzamalli , Dario Neri , Nicholas Favalli

DNA-encoded chemical libraries enable the discovery of potent PSMA-ligands with substantially reduced affinity towards the GCPIII anti-target.

Chemical science

Avec: Laura Lucaroni , Sebastian Oehler , Tony Georgiev , Marco Müller , Matilde Bocci , Roberto De Luca , Nicholas Favalli , Dario Neri , Samuele Cazzamalli , Luca Prati

Preclinical Evaluation of

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Avec: Andrea Galbiati , Matilde Bocci , Domenico Ravazza , Jacqueline Mock , Ettore Gilardoni , Dario Neri , Samuele Cazzamalli

Molecular Evolution of Multivalent OncoFAP Derivatives with Enhanced Tumor Uptake and Prolonged Tumor Retention.

Journal of medicinal chemistry

Avec: Andrea Galbiati , Matilde Bocci , Silvia Gervasoni , Eleonora Prodi , Giuliano Malloci , Dario Neri , Samuele Cazzamalli

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8

International journal of cancer

Avec: Emanuele Puca , Philipp Probst , Marco Stringhini , Patrizia Murer , Giovanni Pellegrini , Samuele Cazzamalli , Cornelia Hutmacher , Baptiste Gouyou , Sarah Wulhfard , Mattia Matasci , Alessandra Villa , Dario Neri

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade.

Oncotarget

Avec: Sheila Dakhel , Tiziano Ongaro , Baptiste Gouyou , Mattia Matasci , Alessandra Villa , Dario Neri , Samuele Cazzamalli

Sortase-Mediated Site-Specific Modification of Interleukin-2 for the Generation of a Tumor-Targeting Acetazolamide-Cytokine Conjugate.

ACS omega

Avec: Baptiste Gouyou , Jacopo Millul , Alessandra Villa , Samuele Cazzamalli , Dario Neri , Mattia Matasci

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.

International journal of molecular sciences

Avec: Sheila Dakhel , Christian Lizak , Mattia Matasci , Jacqueline Mock , Alessandra Villa , Dario Neri , Samuele Cazzamalli

Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract.

Journal of medicinal chemistry

Avec: Gabriele Bassi , Nicholas Favalli , Christian Pellegrino , Yuichi Onda , Jörg Scheuermann , Samuele Cazzamalli , Markus G Manz , Dario Neri

Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications.

Nature chemistry

Avec: Nicholas Favalli , Gabriele Bassi , Christian Pellegrino , Jacopo Millul , Roberto De Luca , Samuele Cazzamalli , Su Yang , Anika Trenner , Nour L Mozaffari , Renier Myburgh , Mustafa Moroglu , Stuart J Conway , Alessandro A Sartori , Markus G Manz , Richard A Lerner , Peter K Vogt , Jörg Scheuermann , Dario Neri

Deep Learning Approach for the Discovery of Tumor-Targeting Small Organic Ligands from DNA-Encoded Chemical Libraries.

ACS omega

Avec: Wen Torng , Ilaria Biancofiore , Sebastian Oehler , Jin Xu , Jessica Xu , Ian Watson , Brenno Masina , Luca Prati , Nicholas Favalli , Gabriele Bassi , Dario Neri , Samuele Cazzamalli , Jianwen A Feng

A Comparative Analysis of Fibroblast Activation Protein-Targeted Small Molecule-Drug, Antibody-Drug, and Peptide-Drug Conjugates.

Bioconjugate chemistry

Avec: Aureliano Zana , Claudia Puig-Moreno , Matilde Bocci , Ettore Gilardoni , Cesare Di Nitto , Lucrezia Principi , Domenico Ravazza , Giulia Rotta , Eleonora Prodi , Roberto De Luca , Dario Neri , Samuele Cazzamalli

Réseau de co-auteurs

Dario Neri 33 collaborations

Gabriele Bassi 11 collaborations

Andrea Galbiati 11 collaborations

Nicholas Favalli 11 collaborations

Aureliano Zana 10 collaborations

Jacopo Millul 9 collaborations

Matilde Bocci 9 collaborations

Ettore Gilardoni 9 collaborations

Alessandra Villa 8 collaborations

Luca Prati 8 collaborations

Sebastian Oehler 8 collaborations

Mattia Matasci 8 collaborations

Jörg Scheuermann 7 collaborations

Roberto De Luca 6 collaborations

Jacqueline Mock 5 collaborations

Christian Pellegrino 5 collaborations

Laura Lucaroni 5 collaborations

Baptiste Gouyou 5 collaborations

Sheila Dakhel Plaza 4 collaborations

Abdullah Elsayed 4 collaborations

Lucrezia Principi 4 collaborations

Sara Puglioli 4 collaborations

Markus G Manz 4 collaborations

Sheila Dakhel 4 collaborations

Emanuele Puca 3 collaborations

Domenico Ravazza 3 collaborations

Tony Georgiev 3 collaborations

Eleonora Prodi 3 collaborations

Francesca Migliorini 3 collaborations

Tiziano Ongaro 3 collaborations

Lisa Nadal 2 collaborations

Ilaria Biancofiore 2 collaborations

Etienne J Donckele 2 collaborations

Florent Samain 2 collaborations

Renier Myburgh 2 collaborations

Theo Sturm 2 collaborations

Riccardo Stucchi 2 collaborations

Philipp Backhaus 2 collaborations

Michael Schäfers 2 collaborations

Giulia Rotta 2 collaborations

Marco Müller 2 collaborations

Claudia Comacchio 2 collaborations

Christiane Krudewig 1 collaboration

Andreas Gloger 1 collaboration

Eleonore Schmidt 1 collaboration

Lydia Bisbal Lopez 1 collaboration

Luca Pignataro 1 collaboration

Cesare Gennari 1 collaboration

Alberto Dal Corso 1 collaboration

Michael Sandholzer 1 collaboration

Laura Volta 1 collaboration

Martina Cirillo 1 collaboration

Wolfgang Roll 1 collaboration

Lars Stegger 1 collaboration

Inga Asmus 1 collaboration

Kristina Schira 1 collaboration

Denis Yudin 1 collaboration

Min Jia 1 collaboration

Nenad Ban 1 collaboration

Dave Bushnell 1 collaboration

Roger Kornberg 1 collaboration

Anne Kerschenmeyer 1 collaboration

Philippe Valet 1 collaboration

P Backhaus 1 collaboration

F Gierse 1 collaboration

M C Burg 1 collaboration

F Büther 1 collaboration

I Asmus 1 collaboration

P Dorten 1 collaboration

J Cufe 1 collaboration

W Roll 1 collaboration

D Neri 1 collaboration

S Cazzamalli 1 collaboration

J Millul 1 collaboration

J Mock 1 collaboration

A Galbiati 1 collaboration

A Zana 1 collaboration

K P Schäfers 1 collaboration

S Hermann 1 collaboration

M Weckesser 1 collaboration

J Tio 1 collaboration

S Wagner 1 collaboration

H-J Breyholz 1 collaboration

M Schäfers 1 collaboration

Francesco Bartoli 1 collaboration

Philip Elsinga 1 collaboration

Luiza Reali Nazario 1 collaboration

Riemer H J A Slart 1 collaboration

Paola Anna Erba 1 collaboration

Paulina Dorten 1 collaboration

Florian Gierse 1 collaboration

Michael Claesener 1 collaboration

Juela Cufe 1 collaboration

Florian Büther 1 collaboration

Klaus Schäfers 1 collaboration

Sven Hermann 1 collaboration

Sahar Ghiasikhou 1 collaboration

Renato Zenobi 1 collaboration

Adrián Gironda-Martínez 1 collaboration

Émile M D Gorre 1 collaboration

Jean-François Gosalbes 1 collaboration

Mosè Fabbri 1 collaboration

Laura Alvigini 1 collaboration

Silvia Gervasoni 1 collaboration

Giuliano Malloci 1 collaboration

Philipp Probst 1 collaboration

Marco Stringhini 1 collaboration

Patrizia Murer 1 collaboration

Giovanni Pellegrini 1 collaboration

Cornelia Hutmacher 1 collaboration

Sarah Wulhfard 1 collaboration

Christian Lizak 1 collaboration

Yuichi Onda 1 collaboration

Su Yang 1 collaboration

Anika Trenner 1 collaboration

Nour L Mozaffari 1 collaboration

Mustafa Moroglu 1 collaboration

Stuart J Conway 1 collaboration

Alessandro A Sartori 1 collaboration

Richard A Lerner 1 collaboration

Peter K Vogt 1 collaboration

Wen Torng 1 collaboration

Jin Xu 1 collaboration

Jessica Xu 1 collaboration

Ian Watson 1 collaboration

Brenno Masina 1 collaboration

Jianwen A Feng 1 collaboration

Claudia Puig-Moreno 1 collaboration

Cesare Di Nitto 1 collaboration