Impact of library input on the hit discovery rate in DNA-encoded chemical library selections.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
08 Nov 2023
08 Nov 2023
Historique:
received:
17
07
2023
accepted:
29
09
2023
medline:
16
11
2023
pubmed:
16
11
2023
entrez:
16
11
2023
Statut:
epublish
Résumé
DNA-encoded chemical libraries (DELs) are powerful drug discovery tools, enabling the parallel screening of millions of DNA-barcoded compounds. We investigated how the DEL input affects the hit discovery rate in DEL screenings. Evaluation of selection fingerprints revealed that the use of approximately 10
Identifiants
pubmed: 37969600
doi: 10.1039/d3sc03688j
pii: d3sc03688j
pmc: PMC10631129
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12026-12033Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
D.N. is a cofounder and shareholder of Philogen, a Swiss-Italian Biotech company that operates in the field of ligand-based pharmacodelivery. S. P., L. P., S. O., G. B., S. C., and N. F. are employees of Philochem AG, the daughter company of Philogen acting as the discovery unit of the group. All the other authors declare no competing interests.
Références
Chembiochem. 2017 May 4;18(9):837-842
pubmed: 28281333
ACS Chem Biol. 2019 Jan 18;14(1):37-49
pubmed: 30452219
Chemistry. 2021 Apr 26;27(24):7160-7167
pubmed: 33586277
Chembiochem. 2019 Apr 1;20(7):955-962
pubmed: 30549160
ACS Comb Sci. 2015 Dec 14;17(12):722-31
pubmed: 26562224
Nat Rev Drug Discov. 2010 Mar;9(3):203-14
pubmed: 20168317
Bioconjug Chem. 2015 Aug 19;26(8):1623-32
pubmed: 26024553
J Med Chem. 2017 Feb 23;60(4):1247-1261
pubmed: 28151659
SLAS Discov. 2020 Jun;25(5):523-529
pubmed: 31858872
ACS Med Chem Lett. 2016 Feb 08;7(4):379-84
pubmed: 27096045
EMBO J. 1994 Jul 15;13(14):3245-60
pubmed: 8045255
ACS Comb Sci. 2019 Oct 14;21(10):650-655
pubmed: 31425646
Nat Chem. 2023 Oct;15(10):1431-1443
pubmed: 37400597
J Am Chem Soc. 2021 Apr 21;143(15):5680-5684
pubmed: 33822597
Angew Chem Int Ed Engl. 2008;47(1):48-56
pubmed: 18080276
Nat Chem. 2018 Apr;10(4):441-448
pubmed: 29556050
Annu Rev Biochem. 2018 Jun 20;87:479-502
pubmed: 29328784
ACS Pharmacol Transl Sci. 2021 Jun 14;4(4):1265-1279
pubmed: 34423264
Nature. 1990 Dec 6;348(6301):552-4
pubmed: 2247164
Chem Sci. 2022 Jan 11;13(4):967-974
pubmed: 35211261
J Theor Biol. 1979 Dec 21;81(4):645-70
pubmed: 94141
Chembiochem. 2017 May 4;18(9):848-852
pubmed: 28220596
Nucleic Acids Res. 1993 May 11;21(9):2265-6
pubmed: 8502579
J Med Chem. 2020 Jul 23;63(14):7840-7856
pubmed: 32584034
Nat Chem. 2021 Jun;13(6):540-548
pubmed: 33833446
J Med Chem. 2021 May 27;64(10):6730-6744
pubmed: 33955740
Nat Protoc. 2016 Apr;11(4):764-80
pubmed: 26985574
Nat Rev Drug Discov. 2017 Feb;16(2):131-147
pubmed: 27932801
Nat Chem Biol. 2014 Mar;10(3):181-7
pubmed: 24390428
Bioorg Med Chem. 2021 Dec 15;52:116508
pubmed: 34800876
Commun Biol. 2020 Dec 17;3(1):782
pubmed: 33335291
Nat Rev Drug Discov. 2016 Sep;15(9):605-619
pubmed: 27417849
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165
pubmed: 28094476