Early upregulation of cytosolic phospholipase A

Amyotrophic Lateral Sclerosis / metabolism Animals Disease Models, Animal Group IV Phospholipases A2 / metabolism Mice Motor Neurons / metabolism Protein Folding Spinal Cord / metabolism Superoxide Dismutase-1 / metabolism Tumor Necrosis Factor-alpha / metabolism Up-Regulation
ALS Cytosolic phospholipase A2α Misfolded SOD1 Motor neurons Mutant SOD1G93A TNFα

Journal

Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974

Informations de publication

Date de publication:
25 Nov 2021
Historique:
received: 01 04 2021
accepted: 17 11 2021
entrez: 26 11 2021
pubmed: 27 11 2021
medline: 18 3 2022
Statut: epublish

Résumé

Amyotrophic lateral sclerosis (ALS) is a fatal multifactorial neurodegenerative disease characterized by the selective death of motor neurons. Cytosolic phospholipase A Immunofluorescence analysis and western blot analysis of misfolded SOD1, cPLA Misfolded SOD1 was detected in the spinal cord of 3 weeks old mutant SOD1 Motor neurons expressing elevated cPLA

Sections du résumé

BACKGROUND BACKGROUND
Amyotrophic lateral sclerosis (ALS) is a fatal multifactorial neurodegenerative disease characterized by the selective death of motor neurons. Cytosolic phospholipase A
METHODS METHODS
Immunofluorescence analysis and western blot analysis of misfolded SOD1, cPLA
RESULTS RESULTS
Misfolded SOD1 was detected in the spinal cord of 3 weeks old mutant SOD1
CONCLUSIONS CONCLUSIONS
Motor neurons expressing elevated cPLA

Identifiants

DOI: 10.1186/s12974-021-02326-5 PMID: 34823547 PMC: PMC8620709
pubmed: 34823547
doi: 10.1186/s12974-021-02326-5
pii: 10.1186/s12974-021-02326-5
pmc: PMC8620709
doi:

Substances chimiques

Tumor Necrosis Factor-alpha 0
Superoxide Dismutase-1 EC 1.15.1.1
Group IV Phospholipases A2 EC 3.1.1.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

274

Subventions

Organisme : Donation
ID : Miss Dorothy Polayes

Informations de copyright

© 2021. The Author(s).

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Auteurs

Yafa Fetfet Malada Edelstein (YF)

Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.

Yulia Solomonov (Y)

Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.

Nurit Hadad (N)

Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.

Leenor Alfahel (L)

Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Adrian Israelson (A)

Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Rachel Levy (R)

Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel. ral@bgu.ac.il.
ORCID: 0000-0002-4169-485X

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Eucaryotes › Animaux › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Phospholipases A › Phospholipases A2 › Cytosolic phospholipases A2 › Group IV phospholipases A2 › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Early upregulation of cytosolic phospholipase A
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Early upregulation of cytosolic phospholipase A