Adrian Israelson

Affiliations

Department of Physiology and Cell Biology, Faculty of Health Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beersheba, Israel.

Publications (16)

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS.

Frontiers in cellular neuroscience

Avec: Anna Shteinfer-Kuzmine , Shirel Argueti , Rajeev Gupta , Neta Shvil , Salah Abu-Hamad , Yael Gropper , Jan Hoeber , Andrea Magrì , Angela Messina , Elena N Kozlova , Varda Shoshan-Barmatz , Adrian Israelson

Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H

Scientific reports

Avec: Shamchal Bakavayev , Nimrod Chetrit , Tatiana Zvagelsky , Rasha Mansour , Maria Vyazmensky , Zeev Barak , Adrian Israelson , Stanislav Engel

Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS.

Scientific reports

Avec: Marcel F Leyton-Jaimes , Patrik Ivert , Jan Hoeber , Yilin Han , Adam Feiler , Chunfang Zhou , Stanislava Pankratova , Varda Shoshan-Barmatz , Adrian Israelson , Elena N Kozlova

Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel.

Biological chemistry

Avec: Sara S Ribeiro , David Gnutt , Salome Azoulay-Ginsburg , Zamira Fetahaj , Ella Spurlock , Felix Lindner , Damon Kuz , Yfat Cohen-Erez , Hanna Rapaport , Adrian Israelson , Arie-Lev Gruzman , Simon Ebbinghaus

Potential roles of gut microbiome and metabolites in modulating ALS in mice.

Nature

Avec: Eran Blacher , Stavros Bashiardes , Hagit Shapiro , Daphna Rothschild , Uria Mor , Mally Dori-Bachash , Christian Kleimeyer , Claudia Moresi , Yotam Harnik , Maya Zur , Michal Zabari , Rotem Ben-Zeev Brik , Denise Kviatcovsky , Niv Zmora , Yotam Cohen , Noam Bar , Izhak Levi , Nira Amar , Tevie Mehlman , Alexander Brandis , Inbal Biton , Yael Kuperman , Michael Tsoory , Leenor Alfahel , Alon Harmelin , Michal Schwartz , Adrian Israelson , Liisa Arike , Malin E V Johansson , Gunnar C Hansson , Marc Gotkine , Eran Segal , Eran Elinav

MIF homolog d-dopachrome tautomerase (D-DT/MIF-2) does not inhibit accumulation and toxicity of misfolded SOD1.

Scientific reports

Avec: Amina Alaskarov , Shir Barel , Shamchal Bakavayev , Joy Kahn , Adrian Israelson

Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis.

Brain : a journal of neurology

Avec: Shamchal Bakavayev , Alexandra Stavsky , Shirel Argueti-Ostrovsky , Galit Yehezkel , Yael Fridmann-Sirkis , Zeev Barak , Daniel Gitler , Adrian Israelson , Stanislav Engel

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis.

Journal of neuroinflammation

Avec: Shir Zaccai , Anna Nemirovsky , Livnat Lerner , Leenor Alfahel , Ekaterina Eremenko , Adrian Israelson , Alon Monsonego

Early upregulation of cytosolic phospholipase A

Journal of neuroinflammation

Avec: Yafa Fetfet Malada Edelstein , Yulia Solomonov , Nurit Hadad , Leenor Alfahel , Adrian Israelson , Rachel Levy

Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS.

International journal of molecular sciences

Avec: Anna Shteinfer-Kuzmine , Shirel Argueti-Ostrovsky , Marcel F Leyton-Jaimes , Uttpal Anand , Salah Abu-Hamad , Ran Zalk , Varda Shoshan-Barmatz , Adrian Israelson

4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.

International journal of molecular sciences

Avec: Leenor Alfahel , Shirel Argueti-Ostrovsky , Shir Barel , Mahmood Ali Saleh , Joy Kahn , Salome Azoulay-Ginsburg , Ayelet Rothstein , Simon Ebbinghaus , Arie Gruzman , Adrian Israelson

Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo.

Biomolecules

Avec: Sigal Fleisher-Berkovich , Yvonne Ventura , Maya Amoyal , Arik Dahan , Valeria Feinshtein , Leenor Alfahel , Adrian Israelson , Nirit Bernstein , Jonathan Gorelick , Shimon Ben-Shabat

AAV2/9-mediated overexpression of MIF inhibits SOD1 misfolding, delays disease onset, and extends survival in mouse models of ALS.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Marcel F Leyton-Jaimes , Joy Kahn , Adrian Israelson

All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration.

Cells

Avec: Shirel Argueti-Ostrovsky , Leenor Alfahel , Joy Kahn , Adrian Israelson

Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding.

ACS chemical neuroscience

Avec: Shamchal Bakavayev , Shirel Argueti , Nachiyappan Venkatachalam , Galit Yehezkel , Alexandra Stavsky , Zeev Barak , Adrian Israelson , Stanislav Engel

Targeting low levels of MIF expression as a potential therapeutic strategy for ALS.

Cell reports. Medicine

Avec: Leenor Alfahel , Thomas Gschwendtberger , Velina Kozareva , Laura Dumas , Rachel Gibbs , Alexander Kertser , Kuti Baruch , Shir Zaccai , Joy Kahn , Nadine Thau-Habermann , Reto Eggenschwiler , Jared Sterneckert , Andreas Hermann , Niveda Sundararaman , Vineet Vaibhav , Jennifer E Van Eyk , Victor F Rafuse , Ernest Fraenkel , Tobias Cantz , Susanne Petri , Adrian Israelson

Réseau de co-auteurs

Leenor Alfahel 7 collaborations

Joy Kahn 5 collaborations

Shamchal Bakavayev 4 collaborations

Shirel Argueti-Ostrovsky 4 collaborations

Varda Shoshan-Barmatz 3 collaborations

Zeev Barak 3 collaborations

Stanislav Engel 3 collaborations

Marcel F Leyton-Jaimes 3 collaborations

Anna Shteinfer-Kuzmine 2 collaborations

Shirel Argueti 2 collaborations

Salah Abu-Hamad 2 collaborations

Jan Hoeber 2 collaborations

Elena N Kozlova 2 collaborations

Salome Azoulay-Ginsburg 2 collaborations

Simon Ebbinghaus 2 collaborations

Shir Barel 2 collaborations

Alexandra Stavsky 2 collaborations

Galit Yehezkel 2 collaborations

Shir Zaccai 2 collaborations

Rajeev Gupta 1 collaboration

Neta Shvil 1 collaboration

Yael Gropper 1 collaboration

Andrea Magrì 1 collaboration

Angela Messina 1 collaboration

Nimrod Chetrit 1 collaboration

Tatiana Zvagelsky 1 collaboration

Rasha Mansour 1 collaboration

Maria Vyazmensky 1 collaboration

Patrik Ivert 1 collaboration

Yilin Han 1 collaboration

Adam Feiler 1 collaboration

Chunfang Zhou 1 collaboration

Stanislava Pankratova 1 collaboration

Sara S Ribeiro 1 collaboration

David Gnutt 1 collaboration

Zamira Fetahaj 1 collaboration

Ella Spurlock 1 collaboration

Felix Lindner 1 collaboration

Damon Kuz 1 collaboration

Yfat Cohen-Erez 1 collaboration

Hanna Rapaport 1 collaboration

Arie-Lev Gruzman 1 collaboration

Eran Blacher 1 collaboration

Stavros Bashiardes 1 collaboration

Hagit Shapiro 1 collaboration

Daphna Rothschild 1 collaboration

Uria Mor 1 collaboration

Mally Dori-Bachash 1 collaboration

Christian Kleimeyer 1 collaboration

Claudia Moresi 1 collaboration

Yotam Harnik 1 collaboration

Maya Zur 1 collaboration

Michal Zabari 1 collaboration

Rotem Ben-Zeev Brik 1 collaboration

Denise Kviatcovsky 1 collaboration

Niv Zmora 1 collaboration

Yotam Cohen 1 collaboration

Noam Bar 1 collaboration

Izhak Levi 1 collaboration

Nira Amar 1 collaboration

Tevie Mehlman 1 collaboration

Alexander Brandis 1 collaboration

Inbal Biton 1 collaboration

Yael Kuperman 1 collaboration

Michael Tsoory 1 collaboration

Alon Harmelin 1 collaboration

Michal Schwartz 1 collaboration

Liisa Arike 1 collaboration

Malin E V Johansson 1 collaboration

Gunnar C Hansson 1 collaboration

Marc Gotkine 1 collaboration

Eran Segal 1 collaboration

Eran Elinav 1 collaboration

Amina Alaskarov 1 collaboration

Yael Fridmann-Sirkis 1 collaboration

Daniel Gitler 1 collaboration

Anna Nemirovsky 1 collaboration

Livnat Lerner 1 collaboration

Ekaterina Eremenko 1 collaboration

Alon Monsonego 1 collaboration

Yafa Fetfet Malada Edelstein 1 collaboration

Yulia Solomonov 1 collaboration

Nurit Hadad 1 collaboration

Rachel Levy 1 collaboration

Uttpal Anand 1 collaboration

Ran Zalk 1 collaboration

Mahmood Ali Saleh 1 collaboration

Ayelet Rothstein 1 collaboration

Arie Gruzman 1 collaboration

Sigal Fleisher-Berkovich 1 collaboration

Yvonne Ventura 1 collaboration

Maya Amoyal 1 collaboration

Arik Dahan 1 collaboration

Valeria Feinshtein 1 collaboration

Nirit Bernstein 1 collaboration

Jonathan Gorelick 1 collaboration

Shimon Ben-Shabat 1 collaboration

Nachiyappan Venkatachalam 1 collaboration

Thomas Gschwendtberger 1 collaboration

Velina Kozareva 1 collaboration

Laura Dumas 1 collaboration

Rachel Gibbs 1 collaboration

Alexander Kertser 1 collaboration

Kuti Baruch 1 collaboration

Nadine Thau-Habermann 1 collaboration

Reto Eggenschwiler 1 collaboration

Jared Sterneckert 1 collaboration

Andreas Hermann 1 collaboration

Niveda Sundararaman 1 collaboration

Vineet Vaibhav 1 collaboration

Jennifer E Van Eyk 1 collaboration

Victor F Rafuse 1 collaboration

Ernest Fraenkel 1 collaboration

Tobias Cantz 1 collaboration

Susanne Petri 1 collaboration