CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis
Antigen presentation
CD4 T cells
Microglia
Neuroinflammation
SOD1 mice
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
11 Jan 2024
11 Jan 2024
Historique:
received:
05
11
2023
accepted:
26
12
2023
medline:
12
1
2024
pubmed:
12
1
2024
entrez:
11
1
2024
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Accumulating evidence suggests that ALS is not solely a neuronal cell- or brain tissue-autonomous disease and that neuroinflammation plays a key role in disease progression. Furthermore, whereas both CD4 and CD8 T cells were observed in spinal cords of ALS patients and in mouse models of the disease, their role in the neuroinflammatory process, especially considering their functional changes with age, is not fully explored. In this study, we revealed the structure of the CD4 T-cell compartment during disease progression of early-onset SOD1
Identifiants
pubmed: 38212835
doi: 10.1186/s12974-023-03007-1
pii: 10.1186/s12974-023-03007-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : Ministry of Science, Technology and Space
ID : 3-16148
Organisme : Israel Science Foundation grant
ID : 284/19
Informations de copyright
© 2024. The Author(s).
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