Anaphylaxis and Mast Cell Disorders.

Anaphylaxis / diagnosis Arthropod Venoms Humans Mast Cells Mastocytosis / diagnosis Tryptases
Anaphylaxis D816 V mutation Hereditary alpha-tryptasemia Mast cell activation syndromes Mast cell hyperreactivity Mastocytosis Tryptase

Journal

Immunology and allergy clinics of North America
ISSN: 1557-8607
Titre abrégé: Immunol Allergy Clin North Am
Pays: United States
ID NLM: 8805635

Informations de publication

Date de publication:
02 2022
Historique:
entrez: 26 11 2021
pubmed: 27 11 2021
medline: 5 1 2022
Statut: ppublish

Résumé

There is strong evidence of an association between severe anaphylaxis, especially hymenoptera venom induced, and mast cell (MC) disorders. It has been thought that intrinsic abnormalities in MCs, including the presence of the activating KIT D816V mutation in mastocytosis or of genetic trait, hereditary alpha-tryptasemia, may influence susceptibility to severe anaphylaxis. This article evaluates the potential mechanisms leading to severe MC activation, as well as the differential diagnosis of and range of symptoms attributable to MC mediator release. Also, we offer a global classification for disorders related to MC activation.

Identifiants

DOI: 10.1016/j.iac.2021.09.007 PMID: 34823750
pubmed: 34823750
pii: S0889-8561(21)00082-5
doi: 10.1016/j.iac.2021.09.007
pii:
doi:

Substances chimiques

Arthropod Venoms 0
Tryptases EC 3.4.21.59

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-63

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure T. Gülen has received lecture fees from Thermo Fisher. C. Akin has received consultancy fees from Blueprint Medicines and Novartis and has a patent for LAD2 cells.

Auteurs

Theo Gülen (T)

Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge; Department of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital; Mastocytosis Centre Karolinska, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Electronic address: theo.gulen@ki.se.

Cem Akin (C)

Department of Internal Medicine, Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Anaphylaxie › Anaphylaxis and Mast Cell Disorders.
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Anaphylaxis and Mast Cell Disorders.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Anaphylaxis and Mast Cell Disorders.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mastocytes › Anaphylaxis and Mast Cell Disorders.
questionsmedicales.fr › Maladies du système immunitaire › Troubles de l'activation mastocytaire › Mastocytose › Anaphylaxis and Mast Cell Disorders.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Tryptases › Anaphylaxis and Mast Cell Disorders.