Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.
Crystallography, X-Ray
DNA Repair
DNA Repair Enzymes
/ chemistry
DNA-Binding Proteins
/ chemistry
HIV-1
/ chemistry
Host-Pathogen Interactions
Humans
Nuclear Magnetic Resonance, Biomolecular
Protein Binding
Protein Interaction Domains and Motifs
Protein Serine-Threonine Kinases
/ chemistry
Protein Structure, Secondary
Ubiquitin-Protein Ligases
/ chemistry
vpr Gene Products, Human Immunodeficiency Virus
/ chemistry
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 11 2021
25 11 2021
Historique:
received:
01
07
2020
accepted:
26
10
2021
entrez:
26
11
2021
pubmed:
27
11
2021
medline:
31
12
2021
Statut:
epublish
Résumé
HIV-1 Vpr is a prototypic member of a large family of structurally related lentiviral virulence factors that antagonize various aspects of innate antiviral immunity. It subverts host cell DNA repair and protein degradation machineries by binding and inhibiting specific post-replication repair enzymes, linking them via the DCAF1 substrate adaptor to the Cullin 4 RING E3 ligase (CRL4
Identifiants
pubmed: 34824204
doi: 10.1038/s41467-021-27009-w
pii: 10.1038/s41467-021-27009-w
pmc: PMC8617076
doi:
Substances chimiques
DNA-Binding Proteins
0
RAD23B protein, human
0
vpr Gene Products, Human Immunodeficiency Virus
0
vpr protein, Human immunodeficiency virus 1
0
RAD23A protein, human
156533-33-4
XPC protein, human
156533-34-5
Ubiquitin-Protein Ligases
EC 2.3.2.27
DCAF1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
DNA Repair Enzymes
EC 6.5.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6864Subventions
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150481
Pays : United States
Organisme : NIH HHS
ID : S10 OD023481
Pays : United States
Informations de copyright
© 2021. The Author(s).
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