Frontal interhemispheric structural connectivity, attention, and executive function in children with perinatal stroke.
ADHD
cerebral palsy
diffusion tensor imaging
executive function
perinatal stroke
tractography
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
18
10
2021
received:
28
05
2021
accepted:
25
10
2021
pubmed:
27
11
2021
medline:
15
3
2022
entrez:
26
11
2021
Statut:
ppublish
Résumé
Perinatal stroke affects ∼1 in 1000 births and concomitant cognitive impairments are common but poorly understood. Rates of Attention Deficit/Hyperactivity Disorder (ADHD) are increased 5-10× and executive dysfunction can be disabling. We used diffusion imaging to investigate whether stroke-related differences in frontal white matter (WM) relate to cognitive impairments. Anterior forceps were isolated using tractography and sampled along the tract. Resulting metrics quantified frontal WM microstructure. Associations between WM metrics and parent ratings of ADHD symptoms (ADHD-5 rating scale) and executive functioning (Behavior Rating Inventory of Executive Function (BRIEF)) were explored. Eighty-three children were recruited (arterial ischemic stroke [AIS] n = 26; periventricular venous infarction [PVI] n = 26; controls n = 31). WM metrics were altered for stroke groups compared to controls. Along-tract analyses showed differences in WM metrics in areas approximating the lesion as well as more remote differences at midline and in the nonlesioned hemisphere. WM metrics correlated with parental ratings of ADHD and executive function such that higher diffusivity values were associated with poorer function. These findings suggest that underlying microstructure of frontal white matter quantified via tractography may provide a relevant biomarker associated with cognition and behavior in children with perinatal stroke.
Identifiants
pubmed: 34825521
doi: 10.1002/brb3.2433
pmc: PMC8785614
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2433Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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