Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.

Animals Antiviral Agents / pharmacokinetics Cells, Cultured Drug Evaluation, Preclinical Female Hep G2 Cells Hepatitis B virus / drug effects Hepatocytes / drug effects Humans Mice Rats Viral Core Proteins / antagonists & inhibitors Virus Assembly / drug effects Virus Replication / drug effects
AB-506 Aminoindane CHB Capsid inhibitor HBV pgRNA encapsidation

Journal

Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699

Informations de publication

Date de publication:
01 2022
Historique:
received: 28 08 2021
revised: 19 11 2021
accepted: 22 11 2021
pubmed: 27 11 2021
medline: 25 2 2022
entrez: 26 11 2021
Statut: ppublish

Résumé

AB-506, a small-molecule inhibitor targeting the HBV core protein, inhibits viral replication in vitro (HepAD38 cells: EC

Identifiants

DOI: 10.1016/j.antiviral.2021.105211 PMID: 34826506
pubmed: 34826506
pii: S0166-3542(21)00201-1
doi: 10.1016/j.antiviral.2021.105211
pii:
doi:

Substances chimiques

Antiviral Agents 0
Viral Core Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105211

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Nagraj Mani (N)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA. Electronic address: nmani@arbutusbio.com.

Andrew G Cole (AG)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Janet R Phelps (JR)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Andrzej Ardzinski (A)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Robbin Burns (R)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Tim Chiu (T)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Andrea Cuconati (A)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Bruce D Dorsey (BD)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Ellen Evangelista (E)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Kristi Fan (K)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Fang Guo (F)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Troy O Harasym (TO)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Salam Kadhim (S)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Roseann Kowalski (R)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Steven G Kultgen (SG)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Amy C H Lee (ACH)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Alice H Li (AH)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Sara A Majeski (SA)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Angela Miller (A)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Chris Pasetka (C)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Stephen P Reid (SP)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Rene Rijnbrand (R)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Holly M Micolochick Steuer (HM)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Kim Stever (K)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Sunny Tang (S)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Xiaowei Teng (X)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Xiaohe Wang (X)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

Michael J Sofia (MJ)

Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, PA, 18974, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Cellules › Cellules cultivées › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Assemblage viral › Preclinical characterization of AB-506, an...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Preclinical characterization of AB-506, an...