Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study.
MGMT promoter methylation
Nicoletti staining
brain tumor
primary spheroid culture
propidium iodide
radioresistance
survival fraction
tumor-initiating cells
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
21 10 2021
21 10 2021
Historique:
received:
24
09
2021
revised:
12
10
2021
accepted:
16
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
13
1
2022
Statut:
epublish
Résumé
Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for therapy resistance and tumor spreading in the brain, reportedly upregulate aldehyde dehydrogenase isoform-1A3 (ALDH1A3) which can be inhibited by disulfiram (DSF), an FDA-approved drug formerly prescribed in alcohol use disorder. Reportedly, DSF in combination with Cu
Identifiants
pubmed: 34827559
pii: biom11111561
doi: 10.3390/biom11111561
pmc: PMC8615869
pii:
doi:
Substances chimiques
Disulfiram
TR3MLJ1UAI
Temozolomide
YF1K15M17Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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