The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review.
biomarkers
infants
neonate
point-of-care
sepsis
septic shock
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Nov 2021
10 Nov 2021
Historique:
received:
18
10
2021
revised:
05
11
2021
accepted:
09
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
18
12
2021
Statut:
epublish
Résumé
Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence varies between 5 and 170 per 1000 births, depending on the social context. In very low birth-weight neonates, the level of mortality increases with the duration of hospitalization, reaching 36% among infants aged 8-14 days and 52% among infants aged 15-28 days. Early diagnosis is the only tool to improve the poor prognosis of neonatal sepsis. Blood culture, the gold standard for diagnosis, is time-consuming and poorly sensitive. C-reactive protein and procalcitonin, currently used as sepsis biomarkers, are influenced by several maternal and fetal pro-inflammatory conditions in the perinatal age. Presepsin is the N-terminal fragment of soluble CD14 subtype (sCD14-ST): it is released in the bloodstream by monocytes and macrophages, in response to bacterial invasion. Presepsin seems to be a new, promising biomarker for the early diagnosis of sepsis in neonates as it is not modified by perinatal confounding inflammatory factors. The aim of the present review is to collect current knowledge about the role of presepsin in critically ill neonates.
Identifiants
pubmed: 34830040
pii: ijms222212154
doi: 10.3390/ijms222212154
pmc: PMC8620326
pii:
doi:
Substances chimiques
CD14 protein, human
0
Lipopolysaccharide Receptors
0
Peptide Fragments
0
Procalcitonin
0
presepsin protein, human
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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