Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential.
DMBT1
FCGBP
TFF3
artificial saliva
esophagus
innate immune defense
lectin
mucin
saliva
xerostomia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Nov 2021
12 Nov 2021
Historique:
received:
27
10
2021
revised:
08
11
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
18
12
2021
Statut:
epublish
Résumé
Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acini of the major and minor salivary glands and are typical constituents of normal saliva; TFF3 being the predominant peptide compared with TFF1 and TFF2. Only TFF3 is easily detectable by Western blotting. It occurs in two forms, a disulfide-linked homodimer (Mr: 13k) and a high-molecular-mass heterodimer with IgG Fc binding protein (FCGBP). TFF peptides are secretory lectins known for their protective effects in mucous epithelia; the TFF3 dimer probably has wound-healing properties due to its weak motogenic effect. There are multiple indications that FCGBP and TFF3-FCGBP play a key role in the innate immune defense of mucous epithelia. In addition, homodimeric TFF3 interacts in vitro with the salivary agglutinin DMBT1
Identifiants
pubmed: 34830103
pii: ijms222212221
doi: 10.3390/ijms222212221
pmc: PMC8624312
pii:
doi:
Substances chimiques
Calcium-Binding Proteins
0
Cell Adhesion Molecules
0
DMBT1 protein, human
0
DNA-Binding Proteins
0
FCGBP protein, human
0
Salivary Proteins and Peptides
0
Trefoil Factors
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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