DNA Repair in Haploid Context.
DNA repair
Saccharomyces cerevisiae
Schizosaccharomyces pombe
diploid
gametes
haploid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Nov 2021
17 Nov 2021
Historique:
received:
01
10
2021
revised:
08
11
2021
accepted:
14
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
22
12
2021
Statut:
epublish
Résumé
DNA repair is a well-covered topic as alteration of genetic integrity underlies many pathological conditions and important transgenerational consequences. Surprisingly, the ploidy status is rarely considered although the presence of homologous chromosomes dramatically impacts the repair capacities of cells. This is especially important for the haploid gametes as they must transfer genetic information to the offspring. An understanding of the different mechanisms monitoring genetic integrity in this context is, therefore, essential as differences in repair pathways exist that differentiate the gamete's role in transgenerational inheritance. Hence, the oocyte must have the most reliable repair capacity while sperm, produced in large numbers and from many differentiation steps, are expected to carry de novo variations. This review describes the main DNA repair pathways with a special emphasis on ploidy. Differences between
Identifiants
pubmed: 34830299
pii: ijms222212418
doi: 10.3390/ijms222212418
pmc: PMC8620282
pii:
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Natural Sciences and Engineering Research Council of Canada
ID : #06089
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