MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ blood
CD146 Antigen
/ blood
Disease Progression
Female
Follow-Up Studies
Gene Expression
Gene Expression Regulation, Neoplastic
Humans
Liquid Biopsy
Longitudinal Studies
Male
Melanoma
/ blood
Middle Aged
Neoplasm Recurrence, Local
/ blood
Neoplasm, Residual
/ blood
Neoplastic Cells, Circulating
/ metabolism
Skin Neoplasms
/ blood
Solubility
Young Adult
Melanoma, Cutaneous Malignant
MCAM/MUC18/CD146
circulating melanoma cells (CMCs)
gene-expression panel
liquid biopsy
soluble CD146
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Nov 2021
17 Nov 2021
Historique:
received:
13
10
2021
revised:
09
11
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
22
12
2021
Statut:
epublish
Résumé
Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular "warning" marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments.
Identifiants
pubmed: 34830300
pii: ijms222212416
doi: 10.3390/ijms222212416
pmc: PMC8623757
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
CD146 Antigen
0
MCAM protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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