Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Nov 2021
Historique:
received: 29 10 2021
revised: 13 11 2021
accepted: 16 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 21 12 2021
Statut: epublish

Résumé

The osmodiuretic agent Mannitol exerts cardioprotection against ischemia and reperfusion (I/R) injury when applied as a pre- and/or postconditioning stimulus. Previously, we demonstrated that these properties are mediated via the activation of mitochondrial ATP-sensitive potassium (mK

Identifiants

pubmed: 34830353
pii: ijms222212471
doi: 10.3390/ijms222212471
pmc: PMC8625521
pii:
doi:

Substances chimiques

Carbazoles 0
Heterocyclic Compounds, 3-Ring 0
KATP Channels 0
MK 2206 0
Receptor, Adenosine A1 0
Xanthines 0
KT 5823 126643-37-6
Mannitol 3OWL53L36A
1,3-dipropyl-8-cyclopentylxanthine 9PTP4FOI9E
Nitric Oxide Synthase Type III EC 1.14.13.39
Nos3 protein, rat EC 1.14.13.39
Akt1 protein, rat EC 2.7.11.1
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Cyclic GMP-Dependent Protein Kinases EC 2.7.11.12

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Carolin Torregroza (C)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Chiara O Glashoerster (CO)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Katharina Feige (K)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Martin Stroethoff (M)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

Annika Raupach (A)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.

André Heinen (A)

Institute of Cardiovascular Physiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.

Markus W Hollmann (MW)

Department of Anesthesiology, Amsterdam University Medical Center (AUMC), Location AMC, Meiberdreef 9, 1105 AZ Amsterdam, The Netherlands.

Ragnar Huhn (R)

Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Department of Anesthesiology, Kerckhoff-Clinic GmbH, Benekestr. 2-8, 61231 Bad Nauheim, Germany.

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Classifications MeSH