Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in
Aminoglycosides
/ pharmacology
Gene Expression Regulation, Bacterial
/ drug effects
Microbial Viability
/ drug effects
Mutation
/ genetics
Quorum Sensing
/ drug effects
SOS Response, Genetics
/ drug effects
Signal Transduction
/ drug effects
Tobramycin
/ pharmacology
Transcriptome
/ genetics
Vibrio cholerae
/ drug effects
SOS response
Vibrio cholerae
aminoglycosides
antibiotic tolerance
bacterial signaling
quorum sensing
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 11 2021
18 11 2021
Historique:
received:
01
10
2021
revised:
15
11
2021
accepted:
16
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
17
12
2021
Statut:
epublish
Résumé
Antibiotics are well known drugs which, when present above certain concentrations, are able to inhibit the growth of certain bacteria. However, a growing body of evidence shows that even when present at lower doses (subMIC, for sub-minimal inhibitory concentration), unable to inhibit or affect microbial growth, antibiotics work as signaling molecules, affect gene expression and trigger important bacterial stress responses. However, how subMIC antibiotic signaling interplays with other well-known signaling networks in bacteria (and the consequences of such interplay) is not well understood. In this work, through transcriptomic and genetic approaches, we have explored how quorum-sensing (QS) proficiency of
Identifiants
pubmed: 34831448
pii: cells10113227
doi: 10.3390/cells10113227
pmc: PMC8621022
pii:
doi:
Substances chimiques
Aminoglycosides
0
Tobramycin
VZ8RRZ51VK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union's Horizon 2020 research and innovation programme
ID : Marie Sklodowska-Curie grant agreement No 665807
Organisme : Fondation pour la Recherche Médicale
ID : FRM Grant No. DBF20160635736
Organisme : ANR Unibac
ID : ANR-17-CE13-0010-01
Organisme : Institut Pasteur
ID : PTR 245-19
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