Quantitative

HILIC-MS glycan profiling monoclonal antibodies protein subunits quantitative analysis

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
20 Oct 2021
Historique:
received: 06 09 2021
revised: 12 10 2021
accepted: 18 10 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 28 11 2021
Statut: epublish

Résumé

The identification and accurate quantitation of the various glycoforms contained in therapeutic monoclonal antibodies (mAbs) is one of the main analytical needs in the biopharmaceutical industry, and glycosylation represents a crucial critical quality attribute (CQA) that needs to be addressed. Currently, the reference method for performing such identification/quantitation consists of the release of the

Identifiants

pubmed: 34834160
pii: pharmaceutics13111744
doi: 10.3390/pharmaceutics13111744
pmc: PMC8617915
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Bastiaan L Duivelshof (BL)

Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.
School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Steffy Denorme (S)

Research Institute for Chromatography (RIC), President Kennedypark 26, 8500 Kortrijk, Belgium.

Koen Sandra (K)

Research Institute for Chromatography (RIC), President Kennedypark 26, 8500 Kortrijk, Belgium.

Xiaoxiao Liu (X)

Waters Corporation, 34 Maple Street, Milford, MA 01757-3696, USA.

Alain Beck (A)

IRPF-Centre d'Immunologie Pierre-Fabre (CIPF), 5 Avenue Napoléon III, 60497 Saint-Julien-en-Genevois, France.

Matthew A Lauber (MA)

Waters Corporation, 34 Maple Street, Milford, MA 01757-3696, USA.

Davy Guillarme (D)

Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.
School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Valentina D'Atri (V)

Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.
School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Classifications MeSH