Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain.
Animals
Animals, Newborn
Brain
/ drug effects
Brain Injuries
/ etiology
Dietary Supplements
Dose-Response Relationship, Drug
Female
Hypoxia-Ischemia, Brain
/ complications
Lactation
Lactoferrin
/ administration & dosage
Male
Neuroprotection
/ drug effects
Neuroprotective Agents
/ administration & dosage
Pregnancy
Rats
Rats, Wistar
hypoxia–ischemia
lactoferrin
neuroprotection
prematurity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Oct 2021
29 Oct 2021
Historique:
received:
25
09
2021
revised:
22
10
2021
accepted:
25
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Injuries to the developing brain due to hypoxia-ischemia (HI) are common causes of neurological disabilities in preterm babies. HI, with oxygen deprivation to the brain or reduced cerebral blood perfusion due to birth asphyxia, often leads to severe brain damage and sequelae. Injury mechanisms include glutamate excitotoxicity, oxidative stress, blood-brain barrier dysfunction, and exacerbated inflammation. Nutritional intervention is emerging as a therapeutic alternative to prevent and rescue brain from HI injury. Lactoferrin (Lf) is an iron-binding protein present in saliva, tears, and breast milk, which has been shown to have antioxidant, anti-inflammatory and anti-apoptotic properties when administered to mothers as a dietary supplement during pregnancy and/or lactation in preclinical studies of developmental brain injuries. However, despite Lf's promising neuroprotective effects, there is no established dose. Here, we tested three different doses of dietary maternal Lf supplementation using the postnatal day 3 HI model and evaluated the acute neurochemical damage profile using
Identifiants
pubmed: 34836132
pii: nu13113880
doi: 10.3390/nu13113880
pmc: PMC8618330
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bill & Melinda Gates Foundation
ID : Bill and Melinda Gates Foundation Grand Challenges
Pays : United States
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