Genomics of Postprandial Lipidomics in the Genetics of Lipid-Lowering Drugs and Diet Network Study.
Adult
Aged
Delta-5 Fatty Acid Desaturase
/ genetics
Fatty Acid Desaturases
/ genetics
Female
Genome-Wide Association Study
Genomics
Genotype
Humans
Hypolipidemic Agents
/ pharmacology
Lipidomics
Lipids
Male
Meals
Middle Aged
Phenotype
Plasma
Polymorphism, Single Nucleotide
Postprandial Period
/ drug effects
FADS1
FADS2
genomics
lipidomics
postprandial
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Nov 2021
10 Nov 2021
Historique:
received:
15
10
2021
revised:
05
11
2021
accepted:
08
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
22
12
2021
Statut:
epublish
Résumé
Postprandial lipemia (PPL) is an important risk factor for cardiovascular disease. Inter-individual variation in the dietary response to a meal is known to be influenced by genetic factors, yet genes that dictate variation in postprandial lipids are not completely characterized. Genetic studies of the plasma lipidome can help to better understand postprandial metabolism by isolating lipid molecular species which are more closely related to the genome. We measured the plasma lipidome at fasting and 6 h after a standardized high-fat meal in 668 participants from the Genetics of Lipid-Lowering Drugs and Diet Network study (GOLDN) using ultra-performance liquid chromatography coupled to (quadrupole) time-of-flight mass spectrometry. A total of 413 unique lipids were identified. Heritable and responsive lipid species were examined for association with single-nucleotide polymorphisms (SNPs) genotyped on the Affymetrix 6.0 array. The most statistically significant SNP findings were replicated in the Amish Heredity and Phenotype Intervention (HAPI) Heart Study. We further followed up findings from GOLDN with a regional analysis of cytosine-phosphate-guanine (CpGs) sites measured on the Illumina HumanMethylation450 array. A total of 132 lipids were both responsive to the meal challenge and heritable in the GOLDN study. After correction for multiple testing of 132 lipids (α = 5 × 10
Identifiants
pubmed: 34836252
pii: nu13114000
doi: 10.3390/nu13114000
pmc: PMC8617762
pii:
doi:
Substances chimiques
Delta-5 Fatty Acid Desaturase
0
Hypolipidemic Agents
0
Lipids
0
Fatty Acid Desaturases
EC 1.14.19.-
FADS1 protein, human
EC 1.14.19.3
FADS2 protein, human
EC 1.14.19.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Heart Lung and Blood Institute
ID : U01HL137181
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : National Heart Lung and Blood Institute
ID : U01HL072515
Organisme : National Heart Lung and Blood Institute
ID : R01HL091357
Organisme : American Heart Association
ID : 15SDG25760020
Organisme : National Heart Lung and Blood Institute
ID : U01HL072524
Organisme : National Heart Lung and Blood Institute
ID : U01HL084756
Organisme : National Heart Lung and Blood Institute
ID : T32HL007457
Organisme : National Heart Lung and Blood Institute
ID : R01HL104135
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