Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review.
anorexia nervosa
atypical psychedelics
eating disorders
esketamine
ketamine
narrative review
severe-enduring
treatment
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 Nov 2021
20 Nov 2021
Historique:
received:
10
10
2021
revised:
16
11
2021
accepted:
18
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Anorexia nervosa (AN) is a highly complex disorder to treat, especially in severe and enduring cases. Whilst the precise aetiology of the disorder is uncertain, malnutrition and weight loss can contribute to reductions in grey and white matter of the brain, impairments in neuroplasticity and neurogenesis and difficulties with cognitive flexibility, memory and learning. Depression is highly comorbid in AN and may be a barrier to recovery. However, traditional antidepressants are often ineffective in alleviating depressive symptoms in underweight patients with AN. There is an urgent need for new treatment approaches for AN. This review gives a conceptual overview for the treatment of AN with ketamine. Ketamine has rapid antidepressant effects, which are hypothesised to occur via increases in glutamate, with sequelae including increased neuroplasticity, neurogenesis and synaptogenesis. This article provides an overview of the use of ketamine for common psychiatric comorbidities of AN and discusses particular safety concerns and side effects. Potential avenues for future research and specific methodological considerations are explored. Overall, there appears to be ample theoretical background, via several potential mechanisms, that warrant the exploration of ketamine as a treatment for adults with AN.
Identifiants
pubmed: 34836413
pii: nu13114158
doi: 10.3390/nu13114158
pmc: PMC8625822
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Glutamic Acid
3KX376GY7L
Ketamine
690G0D6V8H
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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