Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis.
CD8-positive T-lymphocytes
COVID-19
SARS-CoV-2
pneumonitis
Journal
Pathology
ISSN: 1465-3931
Titre abrégé: Pathology
Pays: England
ID NLM: 0175411
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
18
06
2021
revised:
05
08
2021
accepted:
06
09
2021
pubmed:
28
11
2021
medline:
7
6
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Despite millions of PCR confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, the long-term pathophysiological changes induced by this infection in the lungs and their relationship with possible immune triggers remain incompletely understood. Acute respiratory distress syndrome and subsequent respiratory failure are the most common causes of mortality in hospitalised patients. Severe lung tissue destruction can be due to an overactive immune system that far exceeds the harm that would have been caused by direct virus replication. This study extends our previous investigation and presents detailed histopathological findings on cryotransbronchial biopsy in patients with persistent (range 31-182 days) pneumonitis and severe interstitial inflammatory infiltration in the lungs due to SARS-CoV-2 infection. We describe a novel lung injury pattern associated with SARS-CoV-2 pneumonitis, which manifests as a marked interstitial CD8-positive T-cell lymphocytic infiltration. These findings provide a better understanding of the changes in the lungs that ensue due to SARS-CoV-2 infection.
Identifiants
pubmed: 34836647
pii: S0031-3025(21)00514-6
doi: 10.1016/j.pathol.2021.09.005
pmc: PMC8572726
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-408Informations de copyright
Copyright © 2021 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.
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