High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents.
aerobic glycolysis
electrolyte imbalance
glioblastoma
hepatocellular carcinoma
pH mapping
tumor microenvironment
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
06
11
2021
received:
03
06
2021
accepted:
08
11
2021
pubmed:
28
11
2021
medline:
13
4
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS) methods differ respectively by detecting exchangeable and nonexchangeable proton signals by magnetic resonance. Because CEST contrast depends on both temperature and pH, simultaneous CEST and BIRDS imaging can be employed to separate these contributions. Here, we test if high-resolution pH imaging in vivo is possible with ratiometric CEST calibrated for temperature variations measured by BIRDS. Thulium- and europium-based DOTA-tetraglycinate agents, TmDOTA-(gly)
Substances chimiques
Contrast Media
0
Heterocyclic Compounds, 1-Ring
0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
1HTE449DGZ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4658Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB023366
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007205
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons, Ltd.
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