Variation in glucocorticoid sensitivity and the relation with obesity.
cortisol
glucocorticoid sensitivity
glucocorticoids
obesity
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
27
10
2021
received:
08
09
2021
accepted:
03
11
2021
pubmed:
28
11
2021
medline:
26
4
2022
entrez:
27
11
2021
Statut:
ppublish
Résumé
Increasing evidence points to a relation between increased glucocorticoid (GC) exposure and weight gain. In support, long-term cortisol measurements using hair analysis revealed that many individuals with obesity appear to have cortisol values in the high physiological range. The mechanisms behind this relationship need to be determined in order to develop targeted therapy to reach sustainable weight loss in these subgroups. The effect of GCs is not only determined by the plasma concentration of GCs but also by individual differences in GC sensitivity and the target tissue, which can be analyzed by functional GC assays. GC sensitivity is influenced by multiple genetic and acquired (e.g., disease-related) factors, including intracellular GC availability, hormone binding affinity, and expression levels of the GC receptors and their isoforms, as well as factors involved in the modulation of gene transcription. Interindividual differences in GC sensitivity also play a role in the response to exogenous GCs, with respect to both therapeutic and adverse effects. Accordingly, in this review, we summarize current knowledge on mechanisms that influence GC sensitivity and their relationships with obesity and discuss personalized treatment options targeting the GC receptor.
Identifiants
pubmed: 34837448
doi: 10.1111/obr.13401
pmc: PMC9285588
doi:
Substances chimiques
Glucocorticoids
0
Receptors, Glucocorticoid
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13401Informations de copyright
© 2021 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
Références
Endocr Connect. 2012 Oct 24;1(2):103-11
pubmed: 23781311
Neuroendocrinology. 2019;109(2):171-178
pubmed: 30759443
Mol Cell. 2005 Apr 29;18(3):331-42
pubmed: 15866175
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
Biochim Biophys Acta. 2014 Mar;1842(3):473-81
pubmed: 23735216
Front Endocrinol (Lausanne). 2015 Nov 09;6:170
pubmed: 26617572
J Steroid Biochem Mol Biol. 2005 Apr;94(5):383-94
pubmed: 15876404
BMC Mol Biol. 2004 Oct 26;5(1):19
pubmed: 15507144
Endocr Rev. 2003 Aug;24(4):488-522
pubmed: 12920152
Obesity (Silver Spring). 2007 Aug;15(8):1954-60
pubmed: 17712112
Diabet Med. 2006 Dec;23(12):1281-8
pubmed: 17116176
Transl Psychiatry. 2019 Aug 21;9(1):201
pubmed: 31434874
J Clin Endocrinol Metab. 2018 Oct 1;103(10):3630-3639
pubmed: 30020469
J Steroid Biochem Mol Biol. 2019 Feb;186:142-153
pubmed: 30321666
Horm Res Paediatr. 2011;76(3):145-55
pubmed: 21912096
Biogerontology. 2006 Aug;7(4):231-8
pubmed: 16676134
Genes Dev. 2006 Mar 15;20(6):689-99
pubmed: 16543221
Obesity (Silver Spring). 2017 Mar;25(3):500-501
pubmed: 28229549
Int J Med Sci. 2017 Jun 13;14(7):615-621
pubmed: 28824292
Ann N Y Acad Sci. 2006 Jun;1069:1-9
pubmed: 16855130
Nat Clin Pract Rheumatol. 2008 Oct;4(10):525-33
pubmed: 18762788
Nat Rev Immunol. 2017 Apr;17(4):233-247
pubmed: 28192415
Cell. 1998 May 15;93(4):487-90
pubmed: 9604923
Curr Opin Endocrinol Diabetes Obes. 2014 Aug;21(4):306-11
pubmed: 24983396
Clin Endocrinol (Oxf). 2003 Jul;59(1):68-74
pubmed: 12807506
J Clin Endocrinol Metab. 2000 May;85(5):2076-81
pubmed: 10843199
Adv Clin Exp Med. 2017 Jan-Feb;26(1):143-148
pubmed: 28397446
Obes Rev. 2022 Mar;23(3):e13401
pubmed: 34837448
J Clin Endocrinol Metab. 2013 Mar;98(3):E595-9
pubmed: 23393177
Psychoneuroendocrinology. 2017 Jun;80:1-6
pubmed: 28288364
Neuroendocrinology. 2020;110(3-4):282-291
pubmed: 31220843
Steroids. 2011 Sep-Oct;76(10-11):1032-6
pubmed: 21515299
J Clin Endocrinol Metab. 2005 Nov;90(11):5978-84
pubmed: 16091495
J Clin Endocrinol Metab. 1990 Mar;70(3):729-37
pubmed: 2155254
Eur J Endocrinol. 2015 Jan;172(1):69-78
pubmed: 25336506
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):227-32
pubmed: 14694204
J Clin Endocrinol Metab. 2000 Oct;85(10):3733-9
pubmed: 11061532
Neuroimmunomodulation. 2015;22(1-2):6-19
pubmed: 25227402
J Immunol. 2009 Jul 1;183(1):164-71
pubmed: 19542427
Expert Opin Drug Saf. 2016;15(4):457-65
pubmed: 26789102
Eur J Endocrinol. 2015 Oct;173(4):M1-10
pubmed: 25924811
Ann N Y Acad Sci. 2004 Jun;1024:168-81
pubmed: 15265781
J Rheumatol. 2001 Nov;28(11):2383-8
pubmed: 11708406
J Clin Endocrinol Metab. 1993 Jul;77(1):173-7
pubmed: 8392083
Steroids. 2014 Dec;92:62-73
pubmed: 25150015
J Clin Endocrinol Metab. 2013 Jun;98(6):2573-80
pubmed: 23585660
FASEB J. 2009 Nov;23(11):3649-58
pubmed: 19567371
Pediatr Res. 2007 Jul;62(1):26-31
pubmed: 17515840
Neurobiol Learn Mem. 2014 Jul;112:17-29
pubmed: 24113652
J Clin Endocrinol Metab. 2006 Feb;91(2):694-701
pubmed: 16317053
Best Pract Res Clin Endocrinol Metab. 2006 Dec;20(4):611-26
pubmed: 17161335
J Clin Endocrinol Metab. 2005 Oct;90(10):5804-10
pubmed: 16030164
J Clin Endocrinol Metab. 1976 Nov;43(5):1128-33
pubmed: 186477
J Cardiometab Syndr. 2008 Summer;3(3):132-5
pubmed: 18983327
Ann Endocrinol (Paris). 2018 Jun;79(3):107-111
pubmed: 29731108
Mol Endocrinol. 2001 Jul;15(7):1093-103
pubmed: 11435610
J Clin Endocrinol Metab. 2005 May;90(5):2994-3000
pubmed: 15728202
Cancer Res. 2001 May 15;61(10):3937-41
pubmed: 11358809
FASEB J. 2018 Oct;32(10):5626-5639
pubmed: 29733691
Am J Psychiatry. 2014 Oct;171(10):1045-51
pubmed: 25272344
Endocr Rev. 2013 Aug;34(4):525-55
pubmed: 23612224
Biol Chem. 2015 Nov;396(11):1223-31
pubmed: 25910399
Stress. 2018 Sep;21(5):403-416
pubmed: 29764284
Obesity (Silver Spring). 2014 Sep;22(9):1956-8
pubmed: 24852462
Trends Pharmacol Sci. 2013 Sep;34(9):518-30
pubmed: 23953592
J Psychosom Res. 2002 Oct;53(4):865-71
pubmed: 12377295
Neuroendocrinology. 2012;95(3):179-86
pubmed: 22076031
Am J Surg Pathol. 2008 Jun;32(6):874-83
pubmed: 18408592
J Mol Endocrinol. 1992 Dec;9(3):295-300
pubmed: 1362060
Arthritis Res Ther. 2012 Aug 24;14(4):R195
pubmed: 22920577
J Allergy Clin Immunol. 2013 Nov;132(5):1033-44
pubmed: 24084075
J Control Release. 2014 Sep 28;190:624-36
pubmed: 24878183
Ann N Y Acad Sci. 2004 Jun;1024:102-23
pubmed: 15265776
Pharmacol Ther. 2012 Apr;134(1):54-67
pubmed: 22212616
Obes Res. 2003 Jun;11(6):802-8
pubmed: 12805402
Eur J Endocrinol. 2015 Oct;173(4):455-64
pubmed: 26139210
Diabetes. 2002 Oct;51(10):3128-34
pubmed: 12351458
Compr Physiol. 2014 Jul;4(3):965-94
pubmed: 24944027
Life Sci. 1997;61(3):301-8
pubmed: 9217290
J Clin Endocrinol Metab. 2004 Aug;89(8):4004-9
pubmed: 15292341
Pharmacogenomics. 2017 Feb;18(3):293-316
pubmed: 28112586
Psychoneuroendocrinology. 2015 Dec;62:301-18
pubmed: 26356039
BMC Med Genet. 2006 May 25;7:50
pubmed: 16725041
Eur J Endocrinol. 2016 Dec;175(6):645-651
pubmed: 27634941
Hum Genet. 1997 May;99(5):663-8
pubmed: 9150737
Eur J Endocrinol. 2020 Feb 01;182(2):R15-R27
pubmed: 31995340
Kidney Int Rep. 2020 Jun 05;5(8):1327-1332
pubmed: 32775836
J Biol Chem. 2011 Feb 4;286(5):3177-84
pubmed: 21149445
Brain Cogn. 2007 Dec;65(3):209-37
pubmed: 17466428
Mol Cell Endocrinol. 2009 Mar 5;300(1-2):7-16
pubmed: 19000736
Arch Intern Med. 2008 Jan 14;168(1):33-9
pubmed: 18195193
Rheumatology (Oxford). 2011 Nov;50(11):1982-90
pubmed: 21393338
J Clin Endocrinol Metab. 2000 Jan;85(1):14-21
pubmed: 10634357
J Clin Endocrinol Metab. 2017 Oct 1;102(10):3765-3774
pubmed: 28973553
J Clin Invest. 1986 Nov;78(5):1270-8
pubmed: 3771797
Curr Obes Rep. 2018 Jun;7(2):193-203
pubmed: 29663153
Nat Rev Endocrinol. 2009 Jul;5(7):374-81
pubmed: 19488073
Gut. 1999 Sep;45(3):382-8
pubmed: 10446106
Endocrine. 2016 Jul;53(1):63-70
pubmed: 26873309
Front Immunol. 2017 Nov 01;8:1324
pubmed: 29163463
Sci Rep. 2017 May 8;7(1):1537
pubmed: 28484221
JCI Insight. 2018 Jan 25;3(2):
pubmed: 29367455
Obes Res. 2000 May;8(3):211-8
pubmed: 10832763
Mol Endocrinol. 2005 Jul;19(7):1687-96
pubmed: 15746190
Arthritis Res Ther. 2010;12(4):R159
pubmed: 20727199
Obesity (Silver Spring). 2006 May;14(5):759-64
pubmed: 16855182
Genome Res. 2009 Dec;19(12):2163-71
pubmed: 19801529
Lancet Diabetes Endocrinol. 2020 Apr;8(4):278-291
pubmed: 32109422
Biomark Res. 2016 Dec 15;4:26
pubmed: 27999674
Transl Psychiatry. 2015 Jun 09;5:e578
pubmed: 26057048
J Clin Endocrinol Metab. 2008 Dec;93(12):4963-8
pubmed: 18827003
West Indian Med J. 2012 Nov;61(8):844-6
pubmed: 23757909
Nat Rev Endocrinol. 2013 Nov;9(11):670-86
pubmed: 24080732
Endocr Rev. 1996 Jun;17(3):245-61
pubmed: 8771358
Cells. 2019 Oct 09;8(10):
pubmed: 31601045
Ann N Y Acad Sci. 2009 Oct;1179:179-98
pubmed: 19906240
Recent Prog Horm Res. 2004;59:333-57
pubmed: 14749509
Obesity (Silver Spring). 2016 Dec;24(12):2515-2521
pubmed: 27740706
PLoS One. 2016 Dec 22;11(12):e0167337
pubmed: 28005982
Int J Obes (Lond). 2016 Oct;40(10):1503-1509
pubmed: 27339603
Clin Endocrinol (Oxf). 2001 Sep;55(3):363-71
pubmed: 11589680
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674