Seawater activates l-amino acid oxidase from the serum of the red-spotted grouper Epinephelusakaara.

Animals Bass / immunology Fish Proteins / metabolism Hydrogen Peroxide L-Amino Acid Oxidase / metabolism Seawater
Blood innate immune molecule Enzyme activity regulation L-amino acid oxidase Red-spotted grouper Epinephelus akaara Wound healing

Journal

Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 27 08 2021
revised: 15 10 2021
accepted: 23 11 2021
pubmed: 29 11 2021
medline: 26 2 2022
entrez: 28 11 2021
Statut: ppublish

Résumé

l-amino acid oxidases (LAOs) catalyze the oxidative deamination of l-amino acid and generate α-keto acid, ammonia, and hydrogen peroxide as byproducts. LAOs showed the variety of bioactivity by the resulting hydrogen peroxide. The serum of the red-spotted grouper Epinephelus akaara contains an LAO (Ea-LAO) with the potential to kill bacterial pathogens Aeromonas salmonicida and Vibrio anguillarum via hydrogen peroxide. However, it is unknown how the grouper tolerates the harmful effects of the serum Ea-LAO byproducts. In this study, we analyzed the kinetics of fish LAOs to understand how they escape the toxicity of byproducts. The LAO activity of grouper serum was suppressed in low-salt solutions such as NaCl, CaCl

Identifiants

DOI: 10.1016/j.fsi.2021.11.035 PMID: 34838986
pubmed: 34838986
pii: S1050-4648(21)00411-3
doi: 10.1016/j.fsi.2021.11.035
pii:
doi:

Substances chimiques

Fish Proteins 0
Hydrogen Peroxide BBX060AN9V
L-Amino Acid Oxidase EC 1.4.3.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

222-232

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Yoichiro Kitani (Y)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ogi Mu 4-1, Noto-Cho, Ishikawa, 927-0553, Japan. Electronic address: yki@se.kanazawa-u.ac.jp.

Yuto Osaka (Y)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ogi Mu 4-1, Noto-Cho, Ishikawa, 927-0553, Japan.

Shoichiro Ishizaki (S)

Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo, 108-8477, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Seawater activates l-amino acid oxidase from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Perciformes › Serran › Seawater activates l-amino acid oxidase from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Seawater activates l-amino acid oxidase from...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Seawater activates l-amino acid oxidase from...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › L-Amino acid oxidase › Seawater activates l-amino acid oxidase from...
questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Eaux salées › Eau de mer › Seawater activates l-amino acid oxidase from...