Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
01
11
2021
received:
15
09
2021
accepted:
15
11
2021
pubmed:
30
11
2021
medline:
15
3
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Direct pathogenic effects of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GAD65) in autoimmune limbic encephalitis (LE) have been questioned due to its intracellular localization. We therefore hypothesized a pathogenic role for T cells. We assessed magnet resonance imaging, neuropsychological and peripheral blood, and CSF flow cytometry data of 10 patients with long-standing GAD65-LE compared to controls in a cross-sectional manner. These data were related to each other within the GAD65-LE group and linked to neuropathological findings in selective hippocampectomy specimen from another two patients. In addition, full-resolution human leukocyte antigen (HLA) genotyping of all patients was performed. Compared to controls, no alteration in hippocampal volume but impaired memory function and elevated fractions of activated HLADR Our data suggest a pathogenic effect of CD8
Identifiants
pubmed: 34841709
doi: 10.1002/acn3.51486
pmc: PMC8670322
doi:
Substances chimiques
Glutamate Decarboxylase
EC 4.1.1.15
glutamate decarboxylase 2
EC 4.1.1.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2289-2301Subventions
Organisme : Novartis Pharma
Informations de copyright
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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