Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues.
D1R agonists
D2R and DAT
Dihydrexidine
Dopamine analogs
SKF 38393
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
11
10
2021
accepted:
17
11
2021
pubmed:
30
11
2021
medline:
5
4
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogues as part of drug development effort to obtain drugs for treatment of neurodegenerative diseases, such as Parkinson's disease. To that end, similarity search of the ZINC database based on two known dopamine-1 receptor (D1R) agonists, dihydrexidine (DHX) and SKF 38393, respectively, was used to predict novel chemical entities with potential binding to D1R. Three compounds that showed the highest similarity index were selected for synthesis and bioactivity profiling. All main synthesis products as well as the isolated intermediates, were properly characterized. The physico-chemical analyses were performed using HRESIMS, GC/MS, LC/MS with UV-Vis detection, and FTIR,
Identifiants
pubmed: 34842969
doi: 10.1007/s00726-021-03106-4
pii: 10.1007/s00726-021-03106-4
doi:
Substances chimiques
Catecholamines
0
Phenanthridines
0
Receptors, Dopamine D1
0
dihydrexidine
32D64VH037
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
67287-49-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-98Subventions
Organisme : FAPESP
ID : 2016/10149-0
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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