RIFM fragrance ingredient safety assessment, phenethyl phenylacetate, CAS Registry Number 102-20-5.
Academies and Institutes
/ standards
Acetates
/ analysis
Animals
Dermatitis, Photoallergic
Dermatitis, Phototoxic
Endpoint Determination
Environmental Exposure
/ adverse effects
Europe
Fertility
/ drug effects
Humans
Mutagenicity Tests
North America
Odorants
/ analysis
Perfume
/ chemistry
Phenols
/ analysis
Phenylacetates
/ analysis
Registries
Reproduction
/ drug effects
Respiratory System
/ drug effects
Risk Assessment
Safety
Skin
/ drug effects
Toxicity Tests
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
15 Jan 2022
15 Jan 2022
Historique:
received:
08
10
2021
accepted:
24
11
2021
pubmed:
30
11
2021
medline:
22
1
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
The existing information supports the use of this material as described in this safety assessment. Phenethyl phenylacetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that phenethyl phenylacetate is not genotoxic. Data provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data on read-across analog benzyl benzoate (CAS # 120-51-4) provide an MOE >100 for the developmental toxicity endpoint. The fertility and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to phenethyl phenylacetate is below the TTC (0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from analog benzyl phenylacetate (CAS # 102-16-9) show that there are no safety concerns for phenethyl phenylacetate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra; phenethyl phenylacetate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; phenethyl phenylacetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.
Identifiants
pubmed: 34843869
pii: S0278-6915(21)00744-4
doi: 10.1016/j.fct.2021.112711
pii:
doi:
Substances chimiques
Acetates
0
Perfume
0
Phenols
0
Phenylacetates
0
phenyl acetate
355G9R500Y
phenylacetic acid
ER5I1W795A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112711Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.