Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells.
Animals
Caffeine
/ pharmacology
Calcium
/ metabolism
Mesenteric Arteries
/ drug effects
Mice
Muscle Contraction
/ drug effects
Muscle, Skeletal
/ drug effects
Muscle, Smooth, Vascular
/ drug effects
Myocytes, Smooth Muscle
/ drug effects
Myography
Physical Conditioning, Animal
/ physiology
Sarcoplasmic Reticulum
/ drug effects
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ metabolism
Sympatholytics
/ pharmacology
Vasoconstrictor Agents
/ pharmacology
Sympatholysis
exercise
sarcoplasmic reticulum
sympathetic vasoconstriction
α-adrenergic receptors
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
12
11
2021
received:
12
11
2021
accepted:
14
11
2021
entrez:
1
12
2021
pubmed:
2
12
2021
medline:
17
3
2022
Statut:
ppublish
Résumé
The vasoconstrictive effect of sympathetic activity is attenuated in contracting skeletal muscle (functional sympatholysis), allowing increased blood supply to the working muscle but the underlying mechanisms are incompletely understood. The purpose of this study was to examine α-adrenergic receptor responsiveness in isolated artery segments from non-exercised and exercised mice, using wire myography. Isometric tension recordings performed on femoral artery segments from exercised mice showed decreased α-adrenergic receptor responsiveness compared to non-exercised mice (logEC
Identifiants
pubmed: 34851043
doi: 10.14814/phy2.15133
pmc: PMC8634630
doi:
Substances chimiques
Sympatholytics
0
Vasoconstrictor Agents
0
Caffeine
3G6A5W338E
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15133Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
Hypertension. 1991 Jun;17(6 Pt 1):723-32
pubmed: 2045132
Physiol Rev. 2003 Oct;83(4):1325-58
pubmed: 14506307
J Physiol. 2017 Aug 1;595(15):5175-5190
pubmed: 28590059
R Soc Open Sci. 2021 Feb 17;8(2):201985
pubmed: 33972875
Med Sci Sports Exerc. 2003 Jan;35(1):27-31
pubmed: 12544631
J Physiol. 2016 Apr 15;594(8):2297-305
pubmed: 26095873
J Physiol. 2002 Apr 1;540(Pt 1):377-86
pubmed: 11927694
J Physiol. 2012 Dec 15;590(24):6269-75
pubmed: 22988143
Circ Res. 1999 Feb 5;84(2):210-9
pubmed: 9933253
J Appl Physiol (1985). 2003 May;94(5):2034-42
pubmed: 12679353
PLoS Biol. 2020 Jul 14;18(7):e3000410
pubmed: 32663219
Clin Sci (Lond). 1980 Apr;58(4):279-86
pubmed: 7379453
Circ Res. 1993 Apr;72(4):778-85
pubmed: 8095186
J Appl Physiol (1985). 2014 Sep 1;117(5):544-55
pubmed: 24876362
Appl Physiol Nutr Metab. 2019 Nov;44(11):1230-1236
pubmed: 30951638
J Appl Physiol (1985). 2004 Aug;97(2):731-8
pubmed: 15247201
J Am Coll Cardiol. 2000 Oct;36(4):1233-8
pubmed: 11028476
J Physiol. 2014 Jul 15;592(14):3063-73
pubmed: 24860173
Circ Res. 1977 Jul;41(1):19-26
pubmed: 862138
J Appl Physiol (1985). 2004 Jul;97(1):393-403
pubmed: 15220322
J Physiol. 2013 Mar 15;591(6):1535-49
pubmed: 23297301
FASEB J. 2005 Jul;19(9):1146-8
pubmed: 15878932
J Sports Med Phys Fitness. 1994 Sep;34(3):217-27
pubmed: 7830384
J Physiol. 2012 Dec 1;590(23):6227-36
pubmed: 22966164
Circ Res. 1962 Sep;11:370-80
pubmed: 13981593
Hypertension. 1986 Jan;8(1):37-44
pubmed: 3080370
J Appl Physiol (1985). 2007 Oct;103(4):1212-20
pubmed: 17656626
Trends Cardiovasc Med. 2006 May;16(4):109-14
pubmed: 16713532
Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H180-H187
pubmed: 29030339
Can J Physiol Pharmacol. 2015 Oct;93(10):843-54
pubmed: 25730320
Microcirculation. 2005 Jan-Feb;12(1):33-45
pubmed: 15804972