Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma.
Anti-Retroviral Agents
/ pharmacology
Carcinogenesis
/ genetics
Cell Proliferation
/ drug effects
Endogenous Retroviruses
/ metabolism
HEK293 Cells
Humans
Meningeal Neoplasms
/ complications
Meningioma
/ complications
Neurilemmoma
/ complications
Neurofibromatosis 2
/ complications
Neurofibromin 2
/ genetics
Signal Transduction
/ drug effects
Transfection
Viral Proteins
/ antagonists & inhibitors
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
20
11
2020
revised:
04
03
2021
accepted:
15
11
2021
pubmed:
3
12
2021
medline:
19
2
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are also relevant in a variety of other tumors. Surgery and radiotherapy are current first-line treatments; however, tumors frequently recur with limited treatment options. Here, we use human Merlin-negative schwannoma and meningioma primary cells to investigate the involvement of the endogenous retrovirus HERV-K in tumor development. HERV-K proteins previously implicated in tumorigenesis were overexpressed in schwannoma and all meningioma grades, and disease-associated CRL4
Identifiants
pubmed: 34853069
pii: 0008-5472.CAN-20-3857
doi: 10.1158/0008-5472.CAN-20-3857
doi:
Substances chimiques
Anti-Retroviral Agents
0
NF2 protein, human
0
Neurofibromin 2
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-247Subventions
Organisme : Medical Research Council
ID : G0701018
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100578
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N004272/1
Pays : United Kingdom
Informations de copyright
©2021 American Association for Cancer Research.
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