Chronic stress facilitates bursting electrical activity in pituitary corticotrophs.
BK channel
HPA axis
chronic stress
corticotrophs
electrophysiology
mathematical modelling
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
12
10
2021
accepted:
18
11
2021
pubmed:
3
12
2021
medline:
27
1
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
Coordination of an appropriate stress response is dependent upon anterior pituitary corticotroph excitability in response to hypothalamic secretagogues and glucocorticoid negative feedback. A key determinant of corticotroph excitability is large conductance calcium- and voltage-activated (BK) potassium channels that are critical for promoting corticotrophin-releasing hormone (CRH)-induced bursting that enhances adrenocorticotrophic hormone secretion. Previous studies revealed hypothalamic-pituitary-adrenal axis hyperexcitability following chronic stress (CS) is partly a function of increased corticotroph output. Thus, we hypothesise that chronic stress promotes corticotroph excitability through a BK-dependent mechanism. Corticotrophs from CS mice displayed significant increase in spontaneous bursting, which was suppressed by the BK blocker paxilline. Mathematical modelling reveals that the time constant of BK channel activation, plus properties and proportion of BK channels functionally coupled to L-type Ca
Substances chimiques
Large-Conductance Calcium-Activated Potassium Channels
0
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-332Subventions
Organisme : Medical Research Council
ID : MR/R010668/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V012290/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010668
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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