Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [

Animals Mice Mice, Knockout Nerve Tissue Proteins Obsessive-Compulsive Disorder Oximes Positron-Emission Tomography / methods Pyridines Receptor, Metabotropic Glutamate 5 / metabolism
Metabotropic glutamate receptor 5 Obsessive-compulsive disorder PET Sapap3 knockout mouse model [(11)C]ABP688 [(18)F]FPEB

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285

Informations de publication

Date de publication:
06 2022
Historique:
received: 25 06 2021
revised: 17 11 2021
accepted: 20 11 2021
pubmed: 3 12 2021
medline: 14 6 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

This study provides a first direct comparison between positron emission tomography radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [ First, wild-type mice (n = 7) received four position emission tomography/computed tomography scans: a [ Using cold FPEB as a blocking compound for [ The current findings substantiate a common binding site and suggest a strong relationship between mGluR5 availability levels measured with both radioligands. In Sapap3 KO mice, a reduced mGluR5 availability could therefore be demonstrated with both radioligands. With [

Sections du résumé

BACKGROUND
This study provides a first direct comparison between positron emission tomography radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [
METHODS
First, wild-type mice (n = 7) received four position emission tomography/computed tomography scans: a [
RESULTS
Using cold FPEB as a blocking compound for [
CONCLUSIONS
The current findings substantiate a common binding site and suggest a strong relationship between mGluR5 availability levels measured with both radioligands. In Sapap3 KO mice, a reduced mGluR5 availability could therefore be demonstrated with both radioligands. With [

Identifiants

DOI: 10.1016/j.bpsc.2021.11.010 PMID: 34856382
pubmed: 34856382
pii: S2451-9022(21)00323-2
doi: 10.1016/j.bpsc.2021.11.010
pii:
doi:

Substances chimiques

3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime 0
Grm5 protein, mouse 0
Nerve Tissue Proteins 0
Oximes 0
Pyridines 0
Receptor, Metabotropic Glutamate 5 0
Sapap3 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

607-615

Informations de copyright

Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Dorien Glorie (D)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium.

Alan Miranda (A)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium.

Stef De Lombaerde (S)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium; Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.

Sigrid Stroobants (S)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium; Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium. Electronic address: steven.staelens@uantwerpen.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Composés chimiques organiques › Amines › Hydroxylamines › Oximes › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Quantification of Metabotropic Glutamate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs métabotropes au glutamate › Récepteur-5 métabotropique du glutamate › Quantification of Metabotropic Glutamate...