Human blastoids model blastocyst development and implantation.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
12
02
2021
accepted:
18
11
2021
pubmed:
3
12
2021
medline:
23
4
2022
entrez:
2
12
2021
Statut:
ppublish
Résumé
One week after fertilization, human embryos implant into the uterus. This event requires the embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo proper. Stem cells can form a blastocyst model that we called a blastoid
Identifiants
pubmed: 34856602
doi: 10.1038/s41586-021-04267-8
pii: 10.1038/s41586-021-04267-8
pmc: PMC8791832
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-605Subventions
Organisme : Austrian Science Fund FWF
ID : M 3131
Pays : Austria
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
Références
Rivron, N. C. et al. Blastocyst-like structures generated solely from stem cells. Nature 557, 106–111 (2018).
doi: 10.1038/s41586-018-0051-0
pubmed: 29720634
Guo, G. et al. Naive pluripotent stem cells derived directly from isolated cells of the human inner cell mass. Stem Cell Rep. 6, 437–446 (2016).
doi: 10.1016/j.stemcr.2016.02.005
Rivron, N. et al. Debate ethics of embryo models from stem cells. Nature 564, 183–185 (2018).
doi: 10.1038/d41586-018-07663-9
pubmed: 30542177
Clark, A. T. et al. Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines. Stem Cell Rep. 16, 1416–1424 (2021).
doi: 10.1016/j.stemcr.2021.05.008
Liu, X. et al. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids. Nature 591, 627–632 (2021).
doi: 10.1038/s41586-021-03372-y
pubmed: 33731926
Yanagida, A. et al. Naive stem cell blastocyst model captures human embryo lineage segregation. Cell Stem Cell 28, 1016–1022 (2021).
doi: 10.1016/j.stem.2021.04.031
pubmed: 33957081
pmcid: 8189436
Yu, L. et al. Blastocyst-like structures generated from human pluripotent stem cells. Nature 591, 620–626 (2021).
doi: 10.1038/s41586-021-03356-y
pubmed: 33731924
Sozen, B. et al. Reconstructing aspects of human embryogenesis with pluripotent stem cells. Nat. Commun. 12, 5550 (2021).
doi: 10.1038/s41467-021-25853-4
pubmed: 34548496
pmcid: 8455697
Fan, Y. et al. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 7, 81 (2021).
doi: 10.1038/s41421-021-00316-8
pubmed: 34489415
pmcid: 8421367
Zhao, C. et al. Reprogrammed iBlastoids contain amnion-like cells but not trophectoderm. Preprint at https://doi.org/10.1101/2021.05.07.442980 (2021).
Meistermann, D. et al. Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification. Cell Stem Cell 28, 1625–1640.e6 (2021).
doi: 10.1016/j.stem.2021.04.027
pubmed: 34004179
Gerri, C. et al. Initiation of a conserved trophectoderm program in human, cow and mouse embryos. Nature 587, 443–447 (2020).
doi: 10.1038/s41586-020-2759-x
pubmed: 32968278
pmcid: 7116563
Rossant, J. Making the mouse blastocyst: past, present, and future. Curr. Top. Dev. Biol. 117, 275–288 (2016).
doi: 10.1016/bs.ctdb.2015.11.015
pubmed: 26969983
Amita, M. et al. Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proc. Natl. Acad. Sci. USA 110, E1212–E1221 (2013).
doi: 10.1073/pnas.1303094110
pubmed: 23493551
pmcid: 3612666
Io, S. et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell 28, 1023–1039.e13 (2021).
doi: 10.1016/j.stem.2021.03.013
pubmed: 33831365
Guo, G. et al. Human naive epiblast cells possess unrestricted lineage potential. Cell Stem Cell 28, 1040–1056.e6 (2021).
doi: 10.1016/j.stem.2021.02.025
pubmed: 33831366
pmcid: 8189439
Hardy, K., Handyside, A. H. & Winston, R. M. The human blastocyst: cell number, death and allocation during late preimplantation development in vitro. Development 107, 597–604 (1989).
doi: 10.1242/dev.107.3.597
pubmed: 2612378
Lewis, W. H. & Gregory, P. W. Cinematographs of living developing rabbit-eggs. Science 69, 226–229 (1929).
doi: 10.1126/science.69.1782.226.b
pubmed: 17789322
Messmer, T. et al. Transcriptional heterogeneity in naive and primed human pluripotent stem cells at single-cell resolution. Cell Rep. 26, 815–824.e4 (2019).
doi: 10.1016/j.celrep.2018.12.099
pubmed: 30673604
pmcid: 6344340
Okae, H. et al. Derivation of human trophoblast stem cells. Cell Stem Cell 22, 50–63.e6 (2018).
doi: 10.1016/j.stem.2017.11.004
pubmed: 29249463
Stirparo, G. G. et al. Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast. Development 145, dev158501 (2018).
doi: 10.1242/dev.158501
pubmed: 29361568
pmcid: 5818005
Linneberg-Agerholm, M. et al. Naïve human pluripotent stem cells respond to Wnt, Nodal, and LIF signalling to produce expandable naïve extra-embryonic endoderm. Development 146, dev180620 (2019).
doi: 10.1242/dev.180620
pubmed: 31740534
Dumortier, J. G. et al. Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst. Science 365, 465–468 (2019).
doi: 10.1126/science.aaw7709
pubmed: 31371608
Boretto, M. et al. Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development 144, 1775–1786 (2017).
pubmed: 28442471
Wang, W. et al. Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Nat. Med. 26, 1644–1653 (2020).
doi: 10.1038/s41591-020-1040-z
pubmed: 32929266
Castel, G. et al. Induction of human trophoblast stem cells from somatic cells and pluripotent stem cells. Cell Rep. 33, 108419 (2020).
doi: 10.1016/j.celrep.2020.108419
pubmed: 33238118
Ma, H. et al. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 366, eaax7890 (2019).
doi: 10.1126/science.aax7890
pubmed: 31672918
Xiang, L. et al. A developmental landscape of 3D-cultured human pre-gastrulation embryos. Nature 577, 537–542 (2020).
doi: 10.1038/s41586-019-1875-y
pubmed: 31830756
Guo, G. et al. Epigenetic resetting of human pluripotency. Development 144, 2748–2763 (2017).
doi: 10.1242/dev.146811
pubmed: 28765214
pmcid: 5560041
Rivron, N. C. et al. Tissue deformation spatially modulates VEGF signaling and angiogenesis. Proc. Natl. Acad. Sci. USA 109, 6886–6891 (2012).
doi: 10.1073/pnas.1201626109
pubmed: 22511716
pmcid: 3344996
Vrij, E. J. et al. 3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates. Lab Chip 16, 734–742 (2016).
doi: 10.1039/C5LC01499A
pubmed: 26775648
Yu, F.-X. et al. Regulation of the Hippo–YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780–791 (2012).
doi: 10.1016/j.cell.2012.06.037
pubmed: 22863277
pmcid: 3433174
Turco, M. Y. et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature 564, 263–267 (2018).
doi: 10.1038/s41586-018-0753-3
pubmed: 30487605
pmcid: 7220805
Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747–2761 (2007).
doi: 10.1101/gad.1602907
pubmed: 17974916
pmcid: 2045129
Kim, S.-I. et al. Inducible transgene expression in human iPS cells using versatile all-in-one piggyBac transposons. Methods Mol. Biol. 1357, 111–131 (2016).
doi: 10.1007/7651_2015_251
pubmed: 26025620
Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171–181 (2014).
doi: 10.1038/nprot.2014.006
pubmed: 24385147
Petropoulos, S. et al. Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos. Cell 165, 1012–1026 (2016).
doi: 10.1016/j.cell.2016.03.023
pubmed: 27062923
pmcid: 4868821
Zhou, F. et al. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature 572, 660–664 (2019).
doi: 10.1038/s41586-019-1500-0
pubmed: 31435013
Tyser, R. C. V. et al. Single-cell transcriptomic characterization of a gastrulating human embryo. Nature 600, 285–289 (2021).
doi: 10.1038/s41586-021-04158-y
pubmed: 34789876
Turco, M. Y. et al. Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nat. Cell Biol. 19, 568–577 (2017).
doi: 10.1038/ncb3516
pubmed: 28394884
pmcid: 5410172
Heijmans, J. et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep. 3, 1128–1139 (2013).
doi: 10.1016/j.celrep.2013.02.031
pubmed: 23545496
Matsuo, M. et al. Levonorgestrel inhibits embryo attachment by eliminating uterine induction of leukemia inhibitory factor. Endocrinology 161, bqz005 (2020).
doi: 10.1210/endocr/bqz005
pubmed: 31638694
Kimmelman, J. et al. New ISSCR guidelines: clinical translation of stem cell research. Lancet 387, 1979–1981 (2016).
doi: 10.1016/S0140-6736(16)30390-7
pubmed: 27179752
Gardner, D. K., Lane, M., Stevens, J., Schlenker, T. & Schoolcraft, W. B. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil. Steril. 73, 1155–1158 (2000).
doi: 10.1016/S0015-0282(00)00518-5
pubmed: 10856474
Mischler, A. et al. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J. Biol. Chem. 296, 100386 (2021).
doi: 10.1016/j.jbc.2021.100386
pubmed: 33556374
pmcid: 7948510
Jeschke, U. et al. The human endometrium expresses the glycoprotein mucin-1 and shows positive correlation for Thomsen–Friedenreich epitope expression and galectin-1 binding. J. Histochem. Cytochem. 57, 871–881 (2009).
doi: 10.1369/jhc.2009.952085
pubmed: 19506091
pmcid: 2728131
Zhang, Y. et al. Cellinker: a platform of ligand–receptor interactions for intercellular communication analysis. Bioinformatics 37, 2025–2032 (2021).
doi: 10.1093/bioinformatics/btab036