Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.

Adenosine Triphosphate Humans Leukemia / drug therapy Macrolides Mitochondrial Proton-Translocating ATPases / chemistry Neoplasms / drug therapy

Journal

Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976

Informations de publication

Date de publication:
04 2022
Historique:
received: 17 05 2021
accepted: 17 09 2021
pubmed: 4 12 2021
medline: 5 4 2022
entrez: 3 12 2021
Statut: ppublish

Résumé

Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains uncertain. We used photoaffinity analogs of the apoptolidins to identify the F

Identifiants

DOI: 10.1038/s41589-021-00900-9 PMID: 34857958 PMC: PMC8967781
pubmed: 34857958
doi: 10.1038/s41589-021-00900-9
pii: 10.1038/s41589-021-00900-9
pmc: PMC8967781
mid: NIHMS1741422
doi:

Substances chimiques

Macrolides 0
Adenosine Triphosphate 8L70Q75FXE
Mitochondrial Proton-Translocating ATPases EC 3.6.3.-
apoptolidin SAO6WVQ23I

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

360-367

Subventions

Organisme : NCI NIH HHS
ID : R01 CA226833
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133552
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL139435
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA247202
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA236131
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM065086
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM092218
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : CIHR
ID : PJT162186
Pays : Canada
Organisme : NCRR NIH HHS
ID : S10 RR019022
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL138291
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Benjamin J Reisman (BJ)

Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Medical Scientist Training Program, Vanderbilt University, Nashville, TN, USA.

Hui Guo (H)

Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Haley E Ramsey (HE)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Madison T Wright (MT)

Department of Chemistry, Vanderbilt University, Nashville, TN, USA.

Bradley I Reinfeld (BI)

Medical Scientist Training Program, Vanderbilt University, Nashville, TN, USA.
Cancer Biology Program, Vanderbilt University, Nashville, TN, USA.

P Brent Ferrell (PB)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cancer Biology Program, Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0003-1140-9154

Gary A Sulikowski (GA)

Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.

W Kimryn Rathmell (WK)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cancer Biology Program, Vanderbilt University, Nashville, TN, USA.

Michael R Savona (MR)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cancer Biology Program, Vanderbilt University, Nashville, TN, USA.

Lars Plate (L)

Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

John L Rubinstein (JL)

Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Brian O Bachmann (BO)

Department of Chemistry, Vanderbilt University, Nashville, TN, USA. brian.bachmann@vanderbilt.edu.
Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA. brian.bachmann@vanderbilt.edu.
ORCID: 0000-0001-5815-1176

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Apoptolidin family glycomacrolides target...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apoptolidin family glycomacrolides target...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Apoptolidin family glycomacrolides target...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Apoptolidin family glycomacrolides target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Mitochondrial Proton-Translocating ATPases › Apoptolidin family glycomacrolides target...
questionsmedicales.fr › Tumeurs › Apoptolidin family glycomacrolides target...