Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases.
blood-brain barrier
brain metastases
breast cancer
drug delivery
Journal
Neuro-oncology advances
ISSN: 2632-2498
Titre abrégé: Neurooncol Adv
Pays: England
ID NLM: 101755003
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
4
12
2021
Statut:
epublish
Résumé
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.
Identifiants
pubmed: 34859240
doi: 10.1093/noajnl/vdab123
pii: vdab123
pmc: PMC8633736
doi:
Types de publication
Journal Article
Langues
eng
Pagination
v133-v143Subventions
Organisme : NCI NIH HHS
ID : F99 CA264445
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA253768
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121322
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
Références
J Cereb Blood Flow Metab. 1997 Nov;17(11):1239-53
pubmed: 9390656
Lancet Oncol. 2002 Jan;3(1):53-7
pubmed: 11905606
Clin Cancer Res. 2003 Jul;9(7):2849-55
pubmed: 12855665
Colloids Surf B Biointerfaces. 2016 May 1;141:260-267
pubmed: 26859117
J Pharmacol Exp Ther. 1994 Apr;269(1):22-7
pubmed: 8169829
Int J Nanomedicine. 2020 Aug 03;15:5491-5501
pubmed: 32848385
Mol Pharm. 2017 Nov 6;14(11):3834-3847
pubmed: 28958145
Cancer Lett. 2021 Apr 1;502:166-179
pubmed: 33450361
Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1487-95
pubmed: 20399573
Cell Stem Cell. 2014 Mar 6;14(3):357-69
pubmed: 24607407
Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):860-6
pubmed: 17011458
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
Am J Pathol. 2010 Jun;176(6):2958-71
pubmed: 20382702
J Pharmacol Exp Ther. 2015 Nov;355(2):264-71
pubmed: 26354993
Adv Pharm Bull. 2017 Sep;7(3):339-348
pubmed: 29071215
J Neurooncol. 2013 May;112(3):461-6
pubmed: 23420398
Nat Rev Clin Oncol. 2020 May;17(5):279-299
pubmed: 32080373
Oncology. 2003;64(1):28-35
pubmed: 12457029
J Control Release. 2019 Jun 10;303:117-129
pubmed: 31026546
Clin Cancer Res. 2009 Oct 1;15(19):6148-57
pubmed: 19789319
Trends Neurosci. 2019 Oct;42(10):667-679
pubmed: 31474310
Neurooncol Adv. 2020 Jun 30;2(1):vdaa071
pubmed: 32666049
Oncotarget. 2017 Jul 26;8(48):83734-83744
pubmed: 29137378
J Cell Biol. 1997 Aug 25;138(4):877-89
pubmed: 9265653
PLoS One. 2014 Jan 08;9(1):e82331
pubmed: 24416140
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Pharmacol Res. 2018 Jun;132:47-68
pubmed: 29604436
Nat Rev Clin Oncol. 2019 Aug;16(8):469-493
pubmed: 30816337
Adv Exp Med Biol. 1980;131:307-19
pubmed: 7435337
J Clin Oncol. 2002 Sep 1;20(17):3644-50
pubmed: 12202665
AAPS J. 2015 Jul;17(4):802-12
pubmed: 25840885
NMR Biomed. 2012 May;25(5):726-36
pubmed: 21954124
BMC Cancer. 2020 Apr 7;20(1):292
pubmed: 32264860
Cell Mol Neurobiol. 2000 Apr;20(2):131-47
pubmed: 10696506
J Pharmacol Exp Ther. 2013 Mar;344(3):655-64
pubmed: 23249624
J Neurooncol. 1988 Sep;6(2):157-68
pubmed: 3225638
Pharm Res. 2018 Jul 12;35(9):177
pubmed: 30003344
Biochemistry (Mosc). 2019 Jul;84(7):762-772
pubmed: 31509727
Surg Oncol. 2012 Sep;21(3):e143-51
pubmed: 22749313
PLoS One. 2016 Feb 24;11(2):e0148613
pubmed: 26910903
BMC Cancer. 2018 Dec 7;18(1):1225
pubmed: 30526520
J Cereb Blood Flow Metab. 2012 Nov;32(11):1959-72
pubmed: 22929442
Oncotarget. 2016 Nov 29;7(48):79401-79407
pubmed: 27765902
Drug Metab Dispos. 2014 Aug;42(8):1292-300
pubmed: 24875464
Am J Pathol. 1992 Nov;141(5):1115-24
pubmed: 1443046
Theranostics. 2020 May 15;10(14):6122-6135
pubmed: 32483443
J Neuropathol Exp Neurol. 2019 Apr 1;78(4):326-339
pubmed: 30816955
Biomed Res Int. 2015;2015:320941
pubmed: 25866775
Cancer Res. 2017 Jan 15;77(2):238-246
pubmed: 27815391
Pharm Res. 2012 Mar;29(3):770-81
pubmed: 22011930
Pharm Res. 2016 Dec;33(12):2930-2942
pubmed: 27528392
Clin Exp Metastasis. 2000;18(6):481-92
pubmed: 11592305
Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1372-80
pubmed: 18355978
Clin Cancer Res. 2010 Oct 1;16(19):4892-8
pubmed: 20719934
Drug Deliv. 2016 Jun;23(5):1788-98
pubmed: 26431064
Front Pharmacol. 2017 Apr 11;8:193
pubmed: 28443023
J Cereb Blood Flow Metab. 2017 Oct;37(10):3300-3317
pubmed: 28753105
Cell Mol Neurobiol. 2000 Apr;20(2):217-30
pubmed: 10696511
Ann Oncol. 2001 Jan;12(1):59-67
pubmed: 11249050
Curr Oncol Rep. 2012 Feb;14(1):48-54
pubmed: 22012633
Neurol Sci. 2011 Feb;32(1):113-6
pubmed: 20924629
Immunol Rev. 2019 Jul;290(1):60-84
pubmed: 31355493
Pharm Res. 2009 Nov;26(11):2486-94
pubmed: 19774344
Neuroradiology. 2006 Oct;48(10):773-81
pubmed: 16937146
Neoplasia. 2021 Jul;23(7):676-691
pubmed: 34139452
Lancet Oncol. 2020 May;21(5):655-663
pubmed: 32251621
J Pharmacol Exp Ther. 2012 Jul;342(1):33-40
pubmed: 22454535
Int J Hyperthermia. 2020 Jul;37(2):35-43
pubmed: 32672118
Clin Cancer Res. 2010 Dec 1;16(23):5664-78
pubmed: 20829328
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8717-E8726
pubmed: 30150398
Front Cell Neurosci. 2014 Aug 04;8:211
pubmed: 25136294
Invest Radiol. 2011 Nov;46(11):718-25
pubmed: 21788908
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E75-E84
pubmed: 27994152
J Physiol. 2000 Oct 1;528 Pt 1:177-87
pubmed: 11018116
Clin Exp Metastasis. 2016 Apr;33(4):373-83
pubmed: 26944053
Mol Pharm. 2014 Nov 3;11(11):4199-207
pubmed: 25243894
J Neurosci Methods. 2013 Sep 30;219(1):188-95
pubmed: 23916719
Clin Anat. 2018 Sep;31(6):812-823
pubmed: 29637627
N Engl J Med. 2014 Feb 20;370(8):699-708
pubmed: 24552317
Ann Oncol. 2011 Nov;22(11):2466-2470
pubmed: 21321089
Pharm Res. 2018 Jan 09;35(2):31
pubmed: 29368289
Int J Neurosci. 2021 Sep 24;:1-8
pubmed: 33843421
Immunotherapy. 2017 Jan;9(2):183-196
pubmed: 28128715
Neuro Oncol. 2010 Mar;12(3):233-42
pubmed: 20167811
J Clin Invest. 2002 Nov;110(9):1309-18
pubmed: 12417570
Anticancer Drugs. 2007 Jan;18(1):23-8
pubmed: 17159499
N Engl J Med. 1971 Nov 18;285(21):1182-6
pubmed: 4938153
N Engl J Med. 2018 Jan 11;378(2):158-168
pubmed: 29320654
Mol Pharm. 2019 Mar 4;16(3):1282-1293
pubmed: 30694684
Nat Commun. 2014 Jun 19;5:4196
pubmed: 24943270
Cancer Res. 2013 Dec 1;73(23):7079-89
pubmed: 24121485
J Control Release. 2012 Nov 10;163(3):277-84
pubmed: 23000189
Transl Oncol. 2016 Jun;9(3):219-27
pubmed: 27267840
Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):934-41
pubmed: 19480972
Ann Oncol. 2014 Dec;25(12):2351-2356
pubmed: 25274615
J Nucl Med. 2019 Apr;60(4):486-491
pubmed: 30237210
Cancer Res. 2000 Sep 1;60(17):4959-67
pubmed: 10987313
J Pharmacol Exp Ther. 2011 Jan;336(1):223-33
pubmed: 20952483
Mol Pharm. 2012 Nov 5;9(11):3236-45
pubmed: 23020847
Radiother Oncol. 1994 Apr;31(1):51-60
pubmed: 8041898
Cancer Discov. 2017 Dec;7(12):1404-1419
pubmed: 29025771
Bioeng Transl Med. 2018 Nov 05;4(1):30-37
pubmed: 30680316
J Nucl Med. 2017 May;58(5):700-705
pubmed: 28153956
J Neurosurg. 1999 Feb;90(2):300-5
pubmed: 9950501
Pharmaceutics. 2020 Dec 11;12(12):
pubmed: 33322488
BMC Cancer. 2015 Oct 13;15:685
pubmed: 26463521
Nat Rev Cancer. 2019 Mar;19(3):133-150
pubmed: 30755690
Nat Rev Cancer. 2016 Feb;16(2):121-6
pubmed: 26822578
Mol Neurobiol. 2019 Sep;56(9):6645-6653
pubmed: 30911935
Clin Cancer Res. 2010 Apr 15;16(8):2443-9
pubmed: 20371685
N Engl J Med. 2018 Aug 23;379(8):722-730
pubmed: 30134131
J Cereb Blood Flow Metab. 2008 Feb;28(2):431-8
pubmed: 17700631
J Neurooncol. 2005 Feb;71(3):281-6
pubmed: 15735918
N Engl J Med. 2014 Feb 20;370(8):709-22
pubmed: 24552318
Oncotarget. 2019 Oct 29;10(59):6334-6348
pubmed: 31695842
Front Pharmacol. 2013 Nov 04;4:136
pubmed: 24312053
Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):185-91
pubmed: 15629610